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Chlormezanone
Trancopal (chlormezanone) is a small molecule pharmaceutical. Chlormezanone was first approved as Trancopal on 1982-01-01. It is used to treat anxiety disorders and muscle spasticity in the USA.
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Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nervous system diseasesD009422
signs and symptoms pathological conditionsD013568
mental disordersD001523
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Chlormezanone
Tradename
Company
Number
Date
Products
TRANCOPALSanofiN-011467 DISCN1982-01-01
2 products
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anxiety disordersEFO_0006788D001008F41.1
muscle spasticityHP_0001257D009128
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
M: Musculo-skeletal system drugs
M03: Muscle relaxants
M03B: Muscle relaxants, centrally acting agents
M03BB: Oxazol, thiazine, and triazine derivatives centrally acting muscle relaxants
M03BB02: Chlormezanone
M03BB52: Chlormezanone, combinations excl. psycholeptics
M03BB72: Chlormezanone, combinations with psycholeptics
HCPCS
No data
Clinical
Indications Phases 4
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Indications Phases 3
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Indications Phases 2
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Indications Phases 1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLORMEZANONE
INNchlormezanone
Description
Chlormezanone is a 1,3-thiazine that is 1,3-thiazinan-4-one S,S-dioxide in which a hydrogen at position 2 is substituted by a 4-chlorophenyl group and the hydrogen attached to the nitrogen is substituted by methyl. A non-benzodiazepine muscle relaxant, it was used in the management of anxiety and in the treatment of muscle spasms until being discontinued worldwide by its manufacturer in 1996, due to rare but serious cutaneous reactions. It has a role as an anxiolytic drug, a muscle relaxant and an antipsychotic agent. It is a 1,3-thiazine, a lactam, a sulfone and a member of monochlorobenzenes.
Classification
Small molecule
Drug class
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN1C(=O)CCS(=O)(=O)C1c1ccc(Cl)cc1
Identifiers
PDB
CAS-ID80-77-3
RxCUI2373
ChEMBL IDCHEMBL1200714
ChEBI ID3619
PubChem CID2717
DrugBankDB01178
UNII IDGP568V9G19 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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