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Chlorhexidine
Avagard, Bioscrub, Chg, Chloraprep, Chloraprep One-step, Chloraprep Swabstick, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Prevantics, Prevantics Swabstick, Soluprep (chlorhexidine) is a small molecule pharmaceutical. Chlorhexidine was first approved as Hibiclens on 1982-01-01. It is used to treat gram-negative bacterial infections, gram-positive bacterial infections, infectious skin diseases, oral candidiasis, and periodontal diseases in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
stomatognathic diseasesD009057
skin and connective tissue diseasesD017437
Trade Name
FDA
EMA
Bioscrub, Chg scrub, Cida-stat, Exidine, Hibiclens, Hibistat, Peridex, Readyprep chg (generic drugs available since 1989-10-24, discontinued: Brian care, E-z scrub, Microderm, Paroex, Periochip, Periogard, Pharmaseal scrub care, Prevacare, Steri-stat)
Combinations
Avagard, Chloraprep one-step, Chloraprep one-step frepp, Chloraprep one-step sepp, Chloraprep single swabstick, Chloraprep triple swabstick, Chloraprep with tint, Prevantics maxi swabstick, Prevantics swab, Prevantics swabstick, Soluprep
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alcohol
+
Chlorhexidine gluconate
Tradename
Company
Number
Date
Products
AVAGARD3MN-021074 OTC2001-06-07
1 products, RLD, RS
Chlorhexidine gluconate
Tradename
Company
Number
Date
Products
PERIDEX3MN-019028 RX1986-08-13
1 products, RLD, RS
CHLORHEXIDINE GLUCONATEBajaj MedicalN-020111 OTC1997-09-11
1 products
CIDA-STATEcolabN-019258 OTC1986-07-22
1 products
CHG SCRUBEcolabN-019258 OTC1986-07-22
1 products
BIOSCRUBK.W. GriffenN-019822 OTC1989-03-31
1 products
READYPREP CHGMedline IndustriesN-207964 OTC2018-11-20
1 products
HIBICLENSMölnlycke Health CareN-017768 OTC1982-01-01
1 products, RLD, RS
HIBISTATMölnlycke Health CareN-018300 OTC1982-01-01
1 products, RLD, RS
CHLORHEXIDINE GLUCONATESage TherapeuticsN-021669 OTC2005-04-25
1 products, RLD, RS
EXIDINEXttrium LaboratoriesN-019125 OTC1984-12-24
1 products
Show 2 marketed
Show 5 discontinued
Chlorhexidine gluconate
+
Isopropyl alcohol
Tradename
Company
Number
Date
Products
SOLUPREP S3MN-208288 OTC2018-08-08
1 products, RLD, RS
CHLORAPREP ONE-STEPBECTON DICKINSON CON-020832 OTC2006-11-21
2 products, RLD, RS
CHLORAPREP WITH TINTBECTON DICKINSON CON-020832 OTC2005-05-03
3 products, RLD, RS
CHLORAPREP ONE-STEPBECTON DICKINSON CON-020832 OTC2003-08-20
1 products, RLD, RS
CHLORAPREP ONE-STEP FREPPBECTON DICKINSON CON-020832 OTC2002-04-26
1 products, RLD, RS
CHLORAPREP ONE-STEPBECTON DICKINSON CON-020832 OTC2000-07-14
1 products, RLD, RS
CHLORAPREP TRIPLE SWABSTICKBECTON DICKINSON CON-021555 OTC2009-06-10
1 products, RLD, RS
CHLORAPREP SINGLE SWABSTICKBECTON DICKINSON CON-021555 OTC2005-05-10
1 products, RLD, RS
CHLORAPREP ONE-STEP SEPPBECTON DICKINSON CON-021555 OTC2002-10-07
1 products, RLD, RS
PREVANTICS SWABPDI Professional Disposables InternationalN-021524 OTC2005-06-03
1 products, RLD, RS
Show 2 marketed
Labels
FDA
EMA
Brand Name
Status
Last Update
3m avagard dOTC monograph not final2023-02-07
3m soluprep sNew Drug Application2023-01-20
bd e-z scrubOTC monograph not final2022-05-18
chloraprep one-stepNew Drug Application2022-12-22
chlorhexidine gluconateANDA2023-06-07
hibiclensNew Drug Application2023-02-03
hibistatNew Drug Application2011-04-19
paroexANDA2021-01-27
peridexExport only2023-03-29
periochipNew Drug Application2021-11-09
Show 5 more
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
gram-negative bacterial infections—D016905—
gram-positive bacterial infections—D016908—
infectious skin diseases—D012874—
oral candidiasisEFO_0007406D002180B37.0
periodontal diseases—D010510K05.6
Agency Specific
FDA
EMA
Expiration
Code
CHLORHEXIDINE GLUCONATE / ISOPROPYL ALCOHOL, SOLUPREP S, 3M HEALTH CARE
2026-01-20M-292
Patent Expiration
Patent
Expires
Flag
FDA Information
Chlorhexidine Gluconate, Chlorhexidine Gluconate, Sage Prods
79350932027-10-02DPU-1022
74275742026-04-25DP
77178892025-02-27DPU-1022
70669162024-02-17U-737
75950212023-05-12DPU-1022
Chlorhexidine Gluconate / Isopropyl Alcohol, Chloraprep One-Step, Becton Dickinson Co
74223882027-04-25DPU-1397
69913942024-01-31DP
71825362023-12-30DP
67297862023-03-14DP
72410652023-03-14DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A01: Stomatological preparations
— A01A: Stomatological preparations
— A01AB: Antiinfectives and antiseptics for local oral treatment
— A01AB03: Chlorhexidine
B: Blood and blood forming organ drugs
— B05: Blood substitutes and perfusion solutions
— B05C: Irrigating solutions, blood substitutes and perfusion
— B05CA: Antiinfective irrigating solutions
— B05CA02: Chlorhexidine
D: Dermatologicals
— D08: Antiseptics and disinfectants
— D08A: Antiseptics and disinfectants
— D08AC: Biguanides and amidines as antiseptics and disinfectants
— D08AC02: Chlorhexidine
— D08AC52: Chlorhexidine, combinations
— D09: Medicated dressings
— D09A: Medicated dressings
— D09AA: Medicated dressings with antiinfectives
— D09AA12: Chlorhexidine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AA: Antiseptic throat preparations
— R02AA05: Chlorhexidine
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AX: Other antiinfectives in atc
— S01AX09: Chlorhexidine
— S02: Otologicals
— S02A: Antiinfective drugs, otologic
— S02AA: Antiinfectives
— S02AA09: Chlorhexidine
— S03: Ophthalmological and otological preparations
— S03A: Antiinfectives, ophthalmologic and otologic
— S03AA: Antiinfectives
— S03AA04: Chlorhexidine
HCPCS
Code
Description
A4248
Chlorhexidine containing antiseptic, 1 ml
Clinical
Clinical Trials
616 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Surgical wound infectionD0135302911131851
GingivitisD005891K05.1014661229
InfectionsD007239EFO_000054411551426
PeriodontitisD010518EFO_0000649K05.3—439925
Covid-19D000086382U07.14814520
Periodontal diseasesD010510K05.6—2331319
Dental cariesD003731EFO_0003819K022271819
Ventilator-associated pneumoniaD053717EFO_1001865J95.8512241716
Dental plaqueD0037733333616
BacteremiaD016470EFO_0003033R78.811—16614
Show 78 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Chronic periodontitisD055113EFO_0006343K05.3121—46
Wounds and injuriesD014947T14.8——1—34
Neonatal sepsisD000071074HP_0040187—11—23
Infant mortalityD007226——2—13
Periapical periodontitisD010485EFO_1001391K04.5——1—23
Postoperative complicationsD011183——2—13
Communicable diseasesD003141——2—13
Esophageal neoplasmsD004938C15—11—23
Respiratory tract infectionsD012141J06.9112——3
NeoplasmsD009369C80——1—12
Show 27 more
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HalitosisD006209R19.611——34
Cystic fibrosisD003550EFO_0000390E84—3———3
Drug-related side effects and adverse reactionsD064420T88.722——13
Coronavirus infectionsD018352EFO_0007224B34.211———2
OsteoarthritisD010003EFO_0002506M15-M1911———2
Cesarean sectionD002585—1——12
Oropharyngeal neoplasmsD009959—1——12
Hiv infectionsD015658EFO_0000764B20—1——12
FeverD005334HP_0001945R50.911———1
WartsD014860B07—1———1
Show 9 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Head and neck neoplasmsD0062581———12
DiseaseD004194EFO_0000408R691———12
Cerebral hemorrhageD0025431————1
Ingrown nailsD009263L60.01————1
RhinoplastyD0122251————1
Pulmonary hypertensionD006976EFO_0001361I27.201————1
Pulmonary heart diseaseD011660I27.811————1
Diabetic angiopathiesD003925EFO_10008961————1
Retinal vein occlusionD012170EFO_1001157H34.811————1
Stomatognathic diseasesD009057K08.91————1
Show 4 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hydrogen-ion concentrationD006863————33
Coronary diseaseD003327————22
Myocardial ischemiaD017202EFO_1001375I20-I25————22
AbscessD000038EFO_0003030————22
FurunculosisD005667L02.92————22
Oral candidiasisD002180EFO_0007406B37.0————22
RosaceaD012393L71————22
Risk reduction behaviorD040242————22
Stomach neoplasmsD013274EFO_0003897C16————22
CicatrixD002921HP_0100699L90.5————22
Show 71 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCHLORHEXIDINE
INNchlorhexidine
Description
Chlorhexidine is a bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge. It has a role as an antiinfective agent and an antibacterial agent. It is a member of biguanides and a member of monochlorobenzenes. It is functionally related to a biguanide.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
N=C(NCCCCCCNC(=N)NC(=N)Nc1ccc(Cl)cc1)NC(=N)Nc1ccc(Cl)cc1
Identifiers
PDB—
CAS-ID55-56-1
RxCUI2358
ChEMBL IDCHEMBL790
ChEBI ID3614
PubChem CID9552079
DrugBankDB00878
UNII IDR4KO0DY52L (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 30,376 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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5,601 adverse events reported
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