Centanafadine
Centanafadine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
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Trade Name
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Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
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Indications
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Agency Specific
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
14 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Attention deficit disorder with hyperactivity | D001289 | EFO_0003888 | F90 | 2 | 1 | 6 | — | — | 9 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Binge-eating disorder | D056912 | F50.2 | — | 1 | — | — | — | 1 | |
| Smoking cessation | D016540 | EFO_0004319 | — | 1 | — | — | — | 1 | |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | CENTANAFADINE |
| INN | centanafadine |
| Description | Centanafadine (INN) (former developmental code name EB-1020) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) that began its development with Euthymics Bioscience after they acquired DOV Pharmaceutical. It was developed as a treatment for attention-deficit hyperactivity disorder (ADHD) and inhibits the reuptake of norepinephrine, dopamine, and serotonin with a ratio of 1:6:14, respectively. In 2011, Euthymics Bioscience spun off its development of centanafadine to a new company called Neurovance. In March 2017, Otsuka Pharmaceutical acquired Neurovance and the rights to centanafadine. As of January 2018, Otsuka's pipeline indicates it is in Phase II and III clinical trials for a number of different applications to medical conditions.
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| Classification | Small molecule |
| Drug class | monoamine transport inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | c1ccc2cc([C@]34CNC[C@H]3C4)ccc2c1 |
Identifiers
| PDB | — |
| CAS-ID | 924012-43-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL3301621 |
| ChEBI ID | — |
| PubChem CID | 16095349 |
| DrugBank | DB14841 |
| UNII ID | D2A6T4UH9C (ChemIDplus, GSRS) |
Target
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Variants
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Trends
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Additional graphs summarizing 18 documents
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Safety
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0 adverse events reported
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