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Cefepime
Maxipime (cefepime) is a small molecule pharmaceutical. Cefepime was first approved as Maxipime on 1996-01-18. It is used to treat acinetobacter infections, bacterial infections, bacterial pneumonia, bacterial skin diseases, and bacteroides infections amongst others in the USA.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
musculoskeletal diseasesD009140
respiratory tract diseasesD012140
urogenital diseasesD000091642
hemic and lymphatic diseasesD006425
skin and connective tissue diseasesD017437
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Maxipime (generic drugs available since 2008-03-20)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cefepime hydrochloride
Tradename
Company
Number
Date
Products
CEFEPIME AND DEXTROSE IN DUPLEX CONTAINERB. Braun MedicalN-050821 RX2010-05-06
2 products
CEFEPIME IN PLASTIC CONTAINERBaxterN-050817 RX2008-08-05
2 products, RLD, RS
MAXIPIMEHospiraN-050679 RX1996-01-18
3 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cefepimeNew Drug Application2020-05-01
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acinetobacter infectionsEFO_1000792D000151
bacterial infectionsD001424A49
bacterial pneumoniaEFO_1001272D018410J15.9
bacterial skin diseasesD017192
bacteroides infectionsEFO_1000832D001442
escherichia coli infectionsEFO_1001318D004927B96.20
feverHP_0001945D005334R50.9
haemophilus infectionsEFO_1001127D006192
infectious bone diseasesD001850
klebsiella infectionsEFO_1001353D007710
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Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
J: Antiinfectives for systemic use
J01: Antibacterials for systemic use
J01D: Other beta-lactam antibacterials in atc
J01DE: Fourth-generation cephalosporins
J01DE01: Cefepime
J01R: Combinations of antibacterials
J01RA: Combinations of antibacterials
J01RA06: Cefepime and amikacin
HCPCS
Code
Description
J0692
Injection, cefepime hydrochloride, 500 mg
Clinical
Clinical Trials
3 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PneumoniaD011014EFO_0003106J1811
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Urinary tract infectionsD014552EFO_0003103N39.011
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCEFEPIME
INNcefepime
Description
Cefepime is a cephalosporin bearing (1-methylpyrrolidinium-1-yl)methyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido groups at positions 3 and 7, respectively, of the cephem skeleton. It has a role as an antibacterial drug. It is a cephalosporin and an oxime O-ether. It is a conjugate base of a cefepime(1+).
Classification
Small molecule
Drug classcephalosporins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CO/N=C(\C(=O)N[C@@H]1C(=O)N2C(C(=O)[O-])=C(C[N+]3(C)CCCC3)CS[C@H]12)c1csc(N)n1
Identifiers
PDB
CAS-ID88040-23-7
RxCUI20481
ChEMBL IDCHEMBL186
ChEBI ID478164
PubChem CID5479537
DrugBankDB01413
UNII ID807PW4VQE3 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
Maxipime - Elan Corporation
$
£
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 19,105 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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943 adverse events reported
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