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Carbetocin
Carbetocin is a protein pharmaceutical. It is currently being investigated in clinical studies. It is known to target oxytocin receptor.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H01: Pituitary and hypothalamic hormones and analogues
— H01B: Posterior pituitary lobe hormones
— H01BB: Oxytocin and analogues
— H01BB03: Carbetocin
HCPCS
No data
Clinical
Clinical Trials
73 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postpartum hemorrhageD006473O72212101732
HemorrhageD006470MP_0001914R58——1225
Uterine inertiaD014593EFO_1001863O62.2———213
PregnancyD011247EFO_0002950Z33.1———2—2
Uterine myomectomyD063186———1—1
Pregnancy complicationsD011248———1—1
AnemiaD000740EFO_0004272D64.9———1—1
Cardiac arrhythmiasD001145EFO_0004269I49.9———1—1
Surgical blood lossD016063———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pre-eclampsiaD011225EFO_0000668O14——2—13
Prader-willi syndromeD011218Orphanet_739Q87.11—11——2
Cesarean sectionD002585111——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
High-risk pregnancyD0185661———12
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PainD010146EFO_0003843R52————11
HyperalgesiaD006930————11
Central nervous system sensitizationD059333————11
Pregnancy rateD018873————11
AnesthesiaD000758————11
MyomaD009214D21————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCARBETOCIN
INNcarbetocin
Description
Carbetocin is oxytocin in which the hydrogen on the phenolic hydroxy group is substituted by methyl, the amino group on the cysteine residue is substituted by hydrogen, and the sulfur of the cysteine residue is replaced by a methylene group. A synthetic carba-analogue of oxytocin, it is used to control bleeding after giving birth. Like oxytocin, it causes contraction of the uterus. It has a role as an oxytocic.
Classification
Protein
Drug classoxytocin derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@@H]1NC(=O)[C@H](Cc2ccc(OC)cc2)NC(=O)CCCSC[C@@H](C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O
Identifiers
PDB—
CAS-ID37025-55-1
RxCUI—
ChEMBL IDCHEMBL3301668
ChEBI ID59204
PubChem CID16681432
DrugBankDB01282
UNII ID88TWF8015Y (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
OXTR
OXTR
Organism
Homo sapiens
Gene name
OXTR
Gene synonyms
NCBI Gene ID
5021
Protein name
oxytocin receptor
Protein synonyms
Uniprot ID
Q15071
Mouse ortholog
Oxtr (18430)
oxytocin receptor (P97926)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 584 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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20 adverse events reported
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