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Carbamazepine
Carbatrol, Equetro, Tegretol (carbamazepine) is a small molecule pharmaceutical. Carbamazepine was first approved as Tegretol on 1982-01-01. It is used to treat bipolar disorder, complex partial epilepsy, mood disorders, post-traumatic stress disorders, and psychotic disorders amongst others in the USA. It is known to target frizzled-8.
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Novartis Pharmaceuticals
Searched
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
stomatognathic diseasesD009057
nervous system diseasesD009422
chemically-induced disordersD064419
mental disordersD001523
Trade Name
FDA
EMA
Carbatrol, Equetro, Tegretol (generic drugs available since 1986-09-17, discontinued: Carnexiv, Teril)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Carbamazepine
Tradename
Company
Number
Date
Products
TEGRETOLNovartisN-016608 RX1982-01-01
1 products, RLD, RS
TEGRETOLNovartisN-018927 RX1987-12-18
1 products, RLD, RS
TEGRETOL-XRNovartisN-020234 RX1996-03-25
3 products, RLD, RS
CARBATROLTakedaN-020712 RX1997-09-30
3 products, RLD
EQUETROValidus PharmaceuticalsN-021710 RX2004-12-10
3 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
carbamazepineANDA2023-06-19
carbatrolNew Drug Application2020-11-17
carnexivNew Drug Application2020-12-04
epitolANDA2021-03-18
equetroNew Drug Application2016-10-06
tegretolNew Drug Application2023-03-23
x-terilOTC monograph not final2022-11-08
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
bipolar disorderEFO_0000289D001714F30.9
complex partial epilepsyEFO_1000877D017029
mood disordersEFO_0004247D019964F30-F39
post-traumatic stress disordersEFO_0001358D013313F43.1
psychotic disordersD011618F20.81
restless legs syndromeEFO_0004270D012148G25.81
schizophreniaEFO_0000692D012559F20
substance withdrawal syndromeEFO_0005800D013375
tonic-clonic epilepsyEFO_0007262D004830
trigeminal neuralgiaEFO_1001219D014277G50.0
Agency Specific
FDA
EMA
Expiration
Code
CARBAMAZEPINE, CARNEXIV, LUNDBECK PHARMS LLC
2023-10-07ODE-124
Patent Expiration
Patent
Expires
Flag
FDA Information
Carbamazepine, Carnexiv, Lundbeck Pharms Llc
115293572040-01-31DP
94935822033-02-27DP
76357732029-03-13DP
84100772029-03-13DP
97508222029-03-13DP
96297972028-11-10U-2004, U-2005, U-2006
97704072028-11-10DP
Carbamazepine, Equetro, Validus Pharms
69772532024-05-19U-693
ATC Codes
N: Nervous system drugs
N03: Antiepileptics
N03A: Antiepileptics
N03AF: Carboxamide derivatives, antiepileptics
N03AF01: Carbamazepine
HCPCS
No data
Clinical
Clinical Trials
93 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.93185421
Bipolar disorderD001714EFO_0000289F30.9128112
SeizuresD012640G40.44127
Trigeminal neuralgiaD014277EFO_1001219G50.011124
Cocaine-related disordersD019970F14314
Substance-related disordersD019966EFO_0003890F13213
NeuralgiaD009437EFO_0009430112
Partial epilepsiesD004828EFO_000426322
AsthmaD001249EFO_0000270J4522
Metabolic clearance rateD00865711
Show 7 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F20112
DementiaD003704F0311
Psychophysiologic disordersD011602F45.911
DepressionD003863F33.911
Anxiety disordersD001008EFO_0006788F41.111
StrokeD020521EFO_0000712I63.911
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Liver cirrhosisD008103EFO_0001422K74.011
Alpha 1-antitrypsin deficiencyD019896E88.0111
Reflex epilepsyD020195EFO_100114611
Infantile spasmsD013036EFO_1000643G40.8211
Hiv infectionsD015658EFO_0000764B2011
VomitingD014839HP_0002013R11.111
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients1515
Hepatitis bD00650911
Hot flashesD01958411
Covid-19D000086382U07.111
Parkinson diseaseD010300EFO_0002508G2011
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Metabolic bone diseasesD001851HP_000093811
OsteoporosisD010024EFO_0003882M81.011
Multiple sclerosisD009103EFO_0003885G3511
Carpal tunnel syndromeD002349EFO_0004143G56.011
Traumatic brain injuriesD000070642S0611
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCARBAMAZEPINE
INNcarbamazepine
Description
Carbamazepine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine carrying a carbamoyl substituent at the azepine nitrogen, used as an anticonvulsant. It has a role as an anticonvulsant, an EC 3.5.1.98 (histone deacetylase) inhibitor, a mitogen, a glutamate transporter activator, an antimanic drug, an analgesic, a non-narcotic analgesic, an environmental contaminant, a xenobiotic, a drug allergen and a sodium channel blocker. It is a dibenzoazepine and a member of ureas.
Classification
Small molecule
Drug classtricyclic compounds
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
NC(=O)N1c2ccccc2C=Cc2ccccc21
Identifiers
PDB
CAS-ID298-46-4
RxCUI2002
ChEMBL IDCHEMBL108
ChEBI ID3387
PubChem CID2554
DrugBankDB00564
UNII ID33CM23913M (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
FZD8
FZD8
Organism
Homo sapiens
Gene name
FZD8
Gene synonyms
NCBI Gene ID
Protein name
frizzled-8
Protein synonyms
frizzled 8, seven transmembrane spanning receptor, frizzled family receptor 8, frizzled homolog 8
Uniprot ID
Mouse ortholog
Fzd8 (14370)
frizzled-8 (Q61091)
Variants
Clinical Variant
Identifier
Target mutation
Effect
Evaluation
Status
VCV000012897SCN1A, 603-91G>Adrug response2021-03-242B
Financial
Carbatrol - Shire
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 30,824 documents
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Safety
Black-box Warning
Black-box warning for: Carbamazepine, Carbatrol, Carnexiv, Epitol, Equetro, Tegretol
Adverse Events
Top Adverse Reactions
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1,864 adverse events reported
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