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Epidiolex, Epidyolex(cannabidiol)
Epidiolex, Epidyolex (cannabidiol) is a small molecule pharmaceutical. Cannabidiol was first approved as Epidiolex on 2018-09-28. It is used to treat anxiety, lennox gastaut syndrome, myoclonic epilepsies, and pain in the USA. It has been approved in Europe to treat lennox gastaut syndrome and myoclonic epilepsies. It is known to target transient receptor potential cation channel subfamily V member 2, G-protein coupled receptor 55, transient receptor potential cation channel subfamily M member 8, N-arachidonyl glycine receptor, transient receptor potential cation channel subfamily A member 1, transient receptor potential cation channel subfamily V member 3, and cannabinoid receptor 1.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
nervous system diseasesD009422
hereditary congenital and neonatal diseases and abnormalitiesD009358
signs and symptoms pathological conditionsD013568
behavior and behavior mechanismsD001520
psychological phenomenaD011579
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
Epidiolex
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Cannabidiol
Tradename
Company
Number
Date
Products
EPIDIOLEXGW ResearchN-210365 RX2018-09-28
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
epidiolexNew Drug Application2020-10-29
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
anxietyEFO_0005230D001007F41.1
lennox gastaut syndromeD065768G40.81
myoclonic epilepsiesEFO_1001900D004831G40.4
painEFO_0003843D010146R52
Agency Specific
FDA
EMA
Expiration
Code
CANNABIDIOL, EPIDIOLEX, GW RES LTD
2027-07-31ODE-326, ODE-332
2025-09-28ODE-216
2023-09-28NCE
2023-07-31NPP
Patent Expiration
Patent
Expires
Flag
FDA Information
Cannabidiol, Epidiolex, Gw Res Ltd
111607952041-03-01U-3233
114066232041-03-01U-3233
112072922039-04-26DPU-3235, U-3236, U-3277
109186082035-10-13U-3071, U-3072, U-3073
110652092035-10-13U-3071
110969052035-10-13DS, DPU-2780, U-2781
114000552035-10-13U-3071
99499372035-06-17U-2421
99561832035-06-17U-2422, U-2423
99561842035-06-17U-2424
99561852035-06-17U-2425
99561862035-06-17U-2426
100925252035-06-17U-2427
101118402035-06-17U-2442, U-2443
101370952035-06-17U-2454, U-2455
106032882035-06-17U-2780, U-2781, U-2782, U-2783
107096712035-06-17U-2862
107096732035-06-17DP
107096742035-06-17U-2780, U-2781
108498602035-06-17U-2427, U-2454
109669392035-06-17DPU-2780, U-2781
111545162035-06-17U-3235, U-3236
113114982035-06-17U-3375, U-3376
113577412035-06-17U-2862
114462582035-06-17U-2780, U-2781, U-3071
116333692035-06-17DPU-2780, U-2781, U-3071
ATC Codes
N: Nervous system drugs
N03: Antiepileptics
N03A: Antiepileptics
N03AX: Other antiepileptics in atc
N03AX24: Cannabidiol
HCPCS
No data
Clinical
Clinical Trials
230 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EpilepsyD004827EFO_0000474G40.94561622
Myoclonic epilepsiesD004831EFO_1001900G40.42361111
Lennox gastaut syndromeD065768G40.812262111
SeizuresD012640G40.431418
AnxietyD001007EFO_0005230F41.13115
Tuberous sclerosisD014402HP_0009720Q85.1314
Social phobiaD000072861EFO_1001917F40.12114
ArthralgiaD018771HP_0002829M25.5112
Knee osteoarthritisD020370EFO_0004616M17112
Postoperative painD010149G89.18112
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Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AlcoholismD000437EFO_0003829F10.14819
Post-traumatic stress disordersD013313EFO_0001358F43.12616
Psychotic disordersD011618F20.812316
Autism spectrum disorderD000067877F84.01314
CannabisD00218822114
Infantile spasmsD013036EFO_1000643G40.82134
Covid-19D000086382U07.11323
PainD010146EFO_0003843R521313
Bipolar disorderD001714EFO_0000289F30.91213
Crohn diseaseD003424EFO_0000384K501313
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Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
SchizophreniaD012559EFO_0000692F2029213
Opioid-related disordersD009293EFO_0005611F11278
Chronic painD059350HP_0012532314
Graft vs host diseaseD006086D89.81244
Breast neoplasmsD001943EFO_0003869C50123
Substance-related disordersD019966EFO_0003890F13213
Colonic neoplasmsD003110C18212
NeoplasmsD009369C80112
Traumatic brain injuriesD000070642S0622
Sturge-weber syndromeD013341Orphanet_3205Q85.89122
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients729
Musculoskeletal painD05935222
PharmacokineticsD010599112
AffectD00033911
VomitingD014839HP_0002013R11.111
NauseaD009325HP_0002018R11.011
CachexiaD002100HP_0004326R6411
Appetitive behaviorD00107011
Prostatic neoplasmsD011471C6111
AdenocarcinomaD00023011
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Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Drug resistant epilepsyD00006927922
FearD00523911
Marijuana abuseD002189EFO_0007191F1211
Adolescent developmentD04192311
Liver diseasesD008107EFO_0001421K70-K7711
MetabolismD008660GO_000815211
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCANNABIDIOL
INNcannabidiol
Description
Cannabidiol is an cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4. It has a role as a plant metabolite. It is a member of resorcinols, an olefinic compound and a phytocannabinoid.
Classification
Small molecule
Drug classcannabinol derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
C=C(C)[C@@H]1CCC(C)=C[C@H]1c1c(O)cc(CCCCC)cc1O
Identifiers
PDB
CAS-ID13956-29-1
RxCUI2045371
ChEMBL IDCHEMBL190461
ChEBI ID69478
PubChem CID644019
DrugBankDB09061
UNII ID19GBJ60SN5 (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
TRPV2
TRPV2
GPR55
GPR55
TRPM8
TRPM8
GPR18
GPR18
TRPA1
TRPA1
TRPV3
TRPV3
CNR1
CNR1
Organism
Homo sapiens
Gene name
TRPV2
Gene synonyms
VRL
NCBI Gene ID
Protein name
transient receptor potential cation channel subfamily V member 2
Protein synonyms
Osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, VRL-1
Uniprot ID
Mouse ortholog
Trpv2 (22368)
transient receptor potential cation channel subfamily V member 2 (Q9WTR1)
Variants
Clinical Variant
No data
Financial
Epidiolex - Jazz Pharmaceuticals
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 12,215 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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43 adverse events reported
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