Calcimar, Forcaltonin(calcitonin salmon)

Forcaltonin, Fortical, Miacalcin (calcitonin salmon) is a protein pharmaceutical. Calcitonin salmon was first approved as Calcimar on 1982-01-01. It has been approved in Europe to treat bone resorption, hypercalcemia, and osteitis deformans. The pharmaceutical is active against calcitonin receptor.

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Therapeutic Areas

Therapeutic Area	MeSH
musculoskeletal diseases	D009140
nutritional and metabolic diseases	D009750
musculoskeletal and neural physiological phenomena	D055687

Trade Name

FDA

EMA

Miacalcin (generic drugs available since 2008-11-17, discontinued: Calcimar, Fortical)

Drug Products

FDA

EMA

New Drug Application (NDA)

Abbreviated New Drug Application (ANDA)

Calcitonin salmon

Tradename	Company	Number	Date	Products
MIACALCIN	Mylan	N-017808 RX	1991-03-29	1 products, RLD, RS

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Calcitonin salmon recombinant

Tradename	Company	Number	Date	Products
FORTICAL	Upsher-Smith Laboratories	N-021406 DISCN	2005-08-12	1 products

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Labels

FDA

EMA

Brand Name	Status	Last Update
calcitonin salmon	ANDA	2023-01-10
fortical	New Drug Application	2010-01-15
miacalcin	New Drug Application	2021-08-15

Indications

FDA

EMA

No data

Agency Specific

FDA

EMA

No data

Patent Expiration

No data

ATC Codes

H: Systemic hormonal preparations, excl. sex hormones and insulins

— H05: Calcium homeostasis

— H05B: Anti-parathyroid agents

— H05BA: Calcitonin preparations

— H05BA01: Calcitonin (salmon synthetic)

— H05BA02: Calcitonin (pork natural)

— H05BA03: Calcitonin (human synthetic)

N: Nervous system drugs

— N02: Analgesics

— N02C: Antimigraine preparations

— N02CD: Calcitonin gene-related peptide (cgrp) antagonists

HCPCS

Code	Description
J0630	Injection, calcitonin salmon, up to 400 units

Clinical

Clinical Trials

44 clinical trials

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Indications Phases 4

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Vitamin d deficiency	D014808	EFO_0003762	E55	1	2	5	2	6	15
Secondary hyperparathyroidism	D006962	EFO_1001173		3	2	5	2	—	11
Chronic kidney failure	D007676	EFO_0003884	N18.6	1	1	1	2	—	4
Asthma	D001249	EFO_0000270	J45	—	—	—	1	—	1
Cardiovascular diseases	D002318	EFO_0000319	I98	—	—	—	1	—	1
Hip fractures	D006620	EFO_0003964	S72.00	—	—	—	1	—	1

Indications Phases 3

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Chronic renal insufficiency	D051436		N18	3	2	5	—	—	9
Covid-19	D000086382		U07.1	—	3	1	—	—	3
Renal insufficiency	D051437	HP_0000083	N19	1	2	2	—	—	3
Myocardial infarction	D009203	EFO_0000612	I21	—	—	1	—	—	1
Hiv infections	D015658	EFO_0000764	B20	—	—	1	—	—	1

Indications Phases 2

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Osteoporosis	D010024	EFO_0003882	M81.0	—	1	—	—	1	2
Coronavirus	D017934			—	1	—	—	—	1
Cytokine release syndrome	D000080424		D89.83	—	1	—	—	—	1
Sars-cov-2	D000086402			—	1	—	—	—	1
Severe acute respiratory syndrome	D045169	EFO_0000694	J12.81	—	1	—	—	—	1
Critical illness	D016638			—	1	—	—	—	1
Acute kidney injury	D058186	HP_0001919	N17	—	1	—	—	—	1

Indications Phases 1

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Prostatic neoplasms	D011471		C61	1	—	—	—	—	1
Breast neoplasms	D001943	EFO_0003869	C50	1	—	—	—	—	1
Bone neoplasms	D001859	EFO_0003820	D16	1	—	—	—	—	1
Hypocalcemia	D006996	HP_0002901	E83.51	1	—	—	—	—	1
Cystic fibrosis	D003550	EFO_0000390	E84	1	—	—	—	—	1

Indications Without Phase

Indication	MeSH	Ontology	ICD-10	Ph 1	Ph 2	Ph 3	Ph 4	Other	Total
Inflammatory bowel diseases	D015212	EFO_0003767		—	—	—	—	1	1
Erectile dysfunction	D007172	EFO_0004234	F52.21	—	—	—	—	1	1
Infections	D007239	EFO_0000544		—	—	—	—	1	1
Liver cirrhosis	D008103	EFO_0001422	K74.0	—	—	—	—	1	1
Psoriasis	D011565	EFO_0000676	L40	—	—	—	—	1	1
Tinea versicolor	D014010	EFO_0007439	B36.0	—	—	—	—	1	1
Obesity	D009765	EFO_0001073	E66.9	—	—	—	—	1	1

Epidemiology

Epidemiological information for investigational and approved indications

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Drug

General

Drug common name	CALCITONIN SALMON
INN	—
Description	Forcaltonin, Fortical, Miacalcin (calcitonin salmon) is a protein pharmaceutical. Calcitonin salmon was first approved as Calcimar on 1982-01-01. It has been approved in Europe to treat bone resorption, hypercalcemia, and osteitis deformans. The pharmaceutical is active against calcitonin receptor.
Classification	Protein
Drug class	vitamin D analogs; anti-inflammatory agents (salicylic acid derivatives)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(N)=O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O

Identifiers

PDB	—
CAS-ID	47931-85-1
RxCUI	—
ChEMBL ID	CHEMBL3989767
ChEBI ID	—
PubChem CID	—
DrugBank	DB00017
UNII ID	—

Target

Agency Approved

CALCR

Organism

Homo sapiens

Gene name

CALCR

Gene synonyms

NCBI Gene ID

799

Protein name

calcitonin receptor

Protein synonyms

Uniprot ID

Q6T712

Mouse ortholog

Calcr (12311)

calcitonin receptor (Q60755)

Alternate

No data

Variants

Clinical Variant

No data

Financial

No data

Trends

PubMed Central

Top Terms for Disease or Syndrome:

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Safety

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Adverse Events

Top Adverse Reactions

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247 adverse events reported

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