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Cibacalcin, Forcaltonin(calcitonin human)
Cibacalcin, Forcaltonin (calcitonin human) is a protein pharmaceutical. Calcitonin human was first approved as Cibacalcin on 1986-10-31. It has been approved in Europe to treat bone resorption, hypercalcemia, and osteitis deformans. The pharmaceutical is active against calcitonin; calcitonin gene-related peptide 1. In addition, it is known to target calcitonin receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nutritional and metabolic diseasesD009750
musculoskeletal and neural physiological phenomenaD055687
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Calcitonin human
Tradename
Company
Number
Date
Products
CIBACALCINNovartisN-018470 DISCN1986-10-31
1 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
H: Systemic hormonal preparations, excl. sex hormones and insulins
— H05: Calcium homeostasis
— H05B: Anti-parathyroid agents
— H05BA: Calcitonin preparations
— H05BA03: Calcitonin (human synthetic)
HCPCS
No data
Clinical
Clinical Trials
142 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PsoriasisD011565EFO_0000676L402830242212108
Skin and connective tissue diseasesD017437—1—1—2
Skin diseasesD012871L00-L99———1—1
Papulosquamous skin diseasesD017444L40-L45———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Squamous cell carcinomaD002294—31——3
Acne vulgarisD000152EFO_0003894L70—11——1
Basal cell carcinomaD002280—11——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Actinic keratosisD055623L57.033——17
Skin neoplasmsD012878EFO_0004198C44—2———2
ImmunotherapyD007167—2———2
Drug-related side effects and adverse reactionsD064420T88.711——12
ArthritisD001168EFO_0005856M05-M1411———1
PruritusD011537HP_0000989L29—1———1
RadiodermatitisD011855L58—1———1
EczemaD004485HP_0000964L30.9—1———1
Atopic dermatitisD003876EFO_0000274L20—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Localized sclerodermaD012594L94.01————1
Breast neoplasmsD001943EFO_0003869C501————1
Healthy volunteers/patients—1————1
Squamous cell neoplasmsD0183071————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Alopecia areataD000506EFO_0004192L63————11
Graft vs host diseaseD006086D89.81————11
Allergic contact dermatitisD017449L23————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameCALCITONIN HUMAN
INN—
Description
Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid (or endostyle) in humans and other chordates in the ultimopharyngeal body. It acts to reduce blood calcium (Ca2+), opposing the effects of parathyroid hormone (PTH).
Classification
Protein
Drug classvitamin D analogs
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC(=O)[C@@H]1CSSC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(N)=O)C(C)C
Identifiers
PDB—
CAS-ID21215-62-3
RxCUI—
ChEMBL IDCHEMBL4594248
ChEBI ID—
PubChem CID—
DrugBank—
UNII ID—
Target
Agency Approved
CALCA
CALCA
Organism
Homo sapiens
Gene name
CALCA
Gene synonyms
CALC1
NCBI Gene ID
796
Protein name
calcitonin; calcitonin gene-related peptide 1
Protein synonyms
Alpha-type CGRP, calcitonin 1, Calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, CGRP-I, katacalcin
Uniprot ID
Q52LX7
Mouse ortholog
Calca (12310)
calcitonin gene-related peptide 1 (Q99JA0)
Alternate
CALCR
CALCR
Organism
Homo sapiens
Gene name
CALCR
Gene synonyms
NCBI Gene ID
799
Protein name
calcitonin receptor
Protein synonyms
Uniprot ID
Q6T712
Mouse ortholog
Calcr (12311)
calcitonin receptor (Q60755)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 56 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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1,326 adverse events reported
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