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Bromocriptine
Cycloset, Parlodel (bromocriptine) is a small molecule pharmaceutical. Bromocriptine was first approved as Parlodel on 1982-01-01. It is used to treat acromegaly, adenoma, amenorrhea, galactorrhea, and hyperprolactinemia amongst others in the USA. The pharmaceutical is active against D(3) dopamine receptor, D(2) dopamine receptor, and D(4) dopamine receptor. In addition, it is known to target 5-hydroxytryptamine receptor 6, 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1B, D(1A) dopamine receptor, D(1B) dopamine receptor, alpha-2C adrenergic receptor, alpha-2B adrenergic receptor, 5-hydroxytryptamine receptor 2A, alpha-2A adrenergic receptor, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1D, 5-hydroxytryptamine receptor 2B, 5-hydroxytryptamine receptor 7, and cytochrome P450 3A4.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
neoplasmsD009369
musculoskeletal diseasesD009140
nervous system diseasesD009422
urogenital diseasesD000091642
skin and connective tissue diseasesD017437
endocrine system diseasesD004700
signs and symptoms pathological conditionsD013568
chemically-induced disordersD064419
Trade Name
FDA
EMA
Cycloset, Parlodel (generic drugs available since 1998-01-13)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bromocriptine mesylate
Tradename
Company
Number
Date
Products
PARLODELValidus PharmaceuticalsN-017962 RX1982-01-01
2 products, RLD
CYCLOSETVeroScienceN-020866 RX2009-05-05
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
cyclosetNew Drug Application2020-11-30
parlodelNew Drug Application2020-01-30
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
acromegaly—D000172—
adenoma—D000236—
amenorrhea—D000568N91.2
galactorrhea—D005687O92.6
hyperprolactinemia—D006966E22.1
hypogonadismHP_0000815D007006E23.0
infertilityEFO_0000545D007246—
neuroleptic malignant syndromeEFO_1001379D009459G21.0
parkinson diseaseEFO_0002508D010300G20
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Bromocriptine Mesylate, Cycloset, Veroscience
84311552032-04-30DPU-976
86139472032-04-30DPU-976
91925762032-04-30DPU-976
95221172032-04-30DPU-976, U-1939
97005552032-04-30DPU-2183, U-2184, U-2185, U-2186, U-2187, U-2188, U-2189, U-2190, U-2191, U-2192, U-2193, U-2194, U-2195, U-2196, U-2197, U-2198
99934742032-04-30U-2384, U-2385, U-2386, U-2387, U-2388, U-2389, U-2390, U-2391, U-2392, U-2393
106880942032-04-30U-2870, U-2871, U-2872, U-2873, U-2874, U-2875, U-2876, U-2877, U-2878, U-2879, U-2880, U-2881, U-2882, U-2883, U-2884, U-2885, U-2886, U-2887, U-2888
110005222032-04-30U-3119, U-3120, U-3121, U-3122
88777082030-06-07DPU-1706
93520252030-06-07U-2111, U-2112, U-2113, U-2114, U-2115, U-2116, U-2117, U-2118, U-2119
98954222030-06-07U-2114, U-2116, U-2281, U-2282, U-2283, U-2284, U-2285, U-2286, U-2287
106881552030-06-07U-2281, U-2890, U-2891, U-2892, U-2893, U-2894, U-2895, U-2896, U-2897, U-2898, U-2899, U-2900, U-2901, U-2902, U-2903, U-2904, U-2905, U-2906, U-2907, U-2908, U-2909, U-2910, U-2911, U-2912, U-2913, U-2914, U-2915, U-2916, U-2917, U-2918, U-2919, U-2920, U-2921, U-2922, U-2923, U-2924, U-2925, U-2926, U-2927, U-2928, U-2929, U-2930, U-2931, U-2932, U-2933, U-2934, U-2935, U-2936, U-2937
78883102023-07-25U-1433
81379922023-07-25U-1433
81379932023-07-25U-1433
81379942023-07-25U-1433
ATC Codes
G: Genito urinary system and sex hormones
— G02: Other gynecologicals in atc
— G02C: Other gynecologicals in atc
— G02CB: Prolactine inhibitors
— G02CB01: Bromocriptine
N: Nervous system drugs
— N04: Anti-parkinson drugs
— N04B: Dopaminergic agents
— N04BC: Dopamine agonists
— N04BC01: Bromocriptine
HCPCS
No data
Clinical
Clinical Trials
11 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hematologic neoplasmsD019337—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LymphomaD008223C85.91————1
Mantle-cell lymphomaD020522C83.11————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0————11
B-cell lymphomaD016393————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBROMOCRIPTINE
INNbromocriptine
Description
Bromocriptine is an indole alkaloid. It has a role as an antiparkinson drug, a hormone antagonist, a dopamine agonist and an antidyskinesia agent. It derives from a hydride of an ergotaman.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@](NC(=O)[C@@H]3C=C4c5cccc6[nH]c(Br)c(c56)C[C@H]4N(C)C3)(C(C)C)C(=O)N12
Identifiers
PDB3UA1
CAS-ID25614-03-3
RxCUI1760
ChEMBL IDCHEMBL493
ChEBI ID3181
PubChem CID31101
DrugBankDB01200
UNII ID3A64E3G5ZO (ChemIDplus, GSRS)
Target
Agency Approved
DRD3
DRD3
DRD2
DRD2
DRD4
DRD4
Organism
Homo sapiens
Gene name
DRD3
Gene synonyms
NCBI Gene ID
1814
Protein name
D(3) dopamine receptor
Protein synonyms
Dopamine D3 receptor, essential tremor 1
Uniprot ID
Q4VBM8
Mouse ortholog
Drd3 (13490)
D(3) dopamine receptor (P30728)
Alternate
HTR6
HTR6
HTR1A
HTR1A
HTR1B
HTR1B
DRD1
DRD1
DRD5
DRD5
ADRA2C
ADRA2C
ADRA2B
ADRA2B
HTR2A
HTR2A
ADRA2A
ADRA2A
HTR2C
HTR2C
HTR1D
HTR1D
HTR2B
HTR2B
HTR7
HTR7
CYP3A4
CYP3A4
Organism
Homo sapiens
Gene name
HTR6
Gene synonyms
NCBI Gene ID
3362
Protein name
5-hydroxytryptamine receptor 6
Protein synonyms
5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled, Serotonin receptor 6
Uniprot ID
Q5TGZ1
Mouse ortholog
Htr6 (15565)
5-hydroxytryptamine receptor 6 (Q9R1C8)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 7,934 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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185 adverse events reported
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