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Azopt(brinzolamide)
Azarga, Azopt, Simbrinza (brinzolamide) is a small molecule pharmaceutical. Brinzolamide was first approved as Azopt on 1998-04-01. It is used to treat open-angle glaucoma in the USA. It has been approved in Europe to treat ocular hypertension and open-angle glaucoma. The pharmaceutical is active against carbonic anhydrase 7. In addition, it is known to target carbonic anhydrase 12, carbonic anhydrase 14, carbonic anhydrase 1, and carbonic anhydrase 2.
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Novartis Pharmaceuticals
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
eye diseasesD005128
Trade Name
FDA
EMA
Azopt (generic drugs available since 2020-11-27)
Combinations
Simbrinza
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Brimonidine tartrate
+
Brinzolamide
Tradename
Company
Number
Date
Products
SIMBRINZAAlcon ResearchN-204251 RX2013-04-19
1 products, RLD, RS
Brinzolamide
Tradename
Company
Number
Date
Products
AZOPTNovartisN-020816 RX1998-04-01
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
azoptNew Drug Application2021-08-02
simbrinzaNew Drug Application2022-12-16
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
open-angle glaucomaEFO_0004190D005902H40.1
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Brimonidine Tartrate / Brinzolamide, Simbrinza, Alcon Labs Inc
90444842030-10-30DP
94212652030-06-17DP
ATC Codes
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01E: Antiglaucoma preparations and miotics
— S01EC: Carbonic anhydrase inhibitors, antiglaucoma drugs and miotics
— S01EC04: Brinzolamide
— S01EC54: Brinzolamide, combinations
HCPCS
No data
Clinical
Clinical Trials
66 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ocular hypertensionD009798EFO_1001069H40.0161618242
Open-angle glaucomaD005902EFO_0004190H40.1—41213130
GlaucomaD005901EFO_0000516H4012819—29
Intraocular pressureD007429———123
Capsule opacificationD058442H26.4———1—1
Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Central serous chorioretinopathyD056833H35.71—1———1
Indications Phases 1
No data
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Eye diseasesD005128EFO_0003966H44————11
CataractD002386EFO_0001059H26.9————11
RetinoschisisD041441H33.10————11
Exfoliation syndromeD017889EFO_0004235————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBRINZOLAMIDE
INNbrinzolamide
Description
Brinzolamide is a sulfonamide and a thienothiazine. It has a role as an antiglaucoma drug and an EC 4.2.1.1 (carbonic anhydrase) inhibitor.
Classification
Small molecule
Drug classcarbonic anhydrase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(S(N)(=O)=O)cc21
Identifiers
PDB4M2V
CAS-ID138890-62-7
RxCUI194881
ChEMBL IDCHEMBL220491
ChEBI ID3176
PubChem CID68844
DrugBankDB01194
UNII ID9451Z89515 (ChemIDplus, GSRS)
Target
Agency Approved
CA7
CA7
Organism
Homo sapiens
Gene name
CA7
Gene synonyms
NCBI Gene ID
766
Protein name
carbonic anhydrase 7
Protein synonyms
CA-VII, Carbonate dehydratase VII, Carbonic anhydrase VII, carbonic dehydratase VII
Uniprot ID
P43166
Mouse ortholog
Car7 (12354)
carbonic anhydrase 7 (Q9ERQ8)
Alternate
CA12
CA12
CA14
CA14
CA1
CA1
CA2
CA2
Organism
Homo sapiens
Gene name
CA12
Gene synonyms
NCBI Gene ID
771
Protein name
carbonic anhydrase 12
Protein synonyms
CA-XII, Carbonate dehydratase XII, Carbonic anhydrase XII, carbonic dehydratase, Tumor antigen HOM-RCC-3.1.3
Uniprot ID
Q9BWG2
Mouse ortholog
Car12 (76459)
carbonic anhydrase 12 (Q8CI85)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 1,337 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,324 adverse events reported
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