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Birinapant
Birinapant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against baculoviral IAP repeat-containing protein 2. In addition, it is known to target E3 ubiquitin-protein ligase XIAP.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
13 clinical trials
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Mock data
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Indications Phases 4
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Indications Phases 3
No data
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8052———5
Fallopian tube neoplasmsD00518522———3
Myelodysplastic syndromesD009190D4612———2
Myeloid leukemia acuteD015470C92.021———2
Ovarian epithelial carcinomaD00007721611———2
Myelomonocytic leukemia chronicD015477C93.1—1———1
Peritoneal neoplasmsD010534—1———1
Ovarian neoplasmsD010051EFO_0003893C5611———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Colorectal neoplasmsD0151791————1
Non-hodgkin lymphomaD008228C85.91————1
SarcomaD0125091————1
B-cell chronic lymphocytic leukemiaD015451C91.11————1
ChondrosarcomaD0028131————1
Hepatitis bD0065091————1
Squamous cell carcinoma of head and neckD0000771951————1
Squamous cell carcinomaD0022941————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBIRINAPANT
INNbirinapant
Description
Birinapant is a dipeptide.
Classification
Small molecule
Drug classinhibitor of apoptosis protein (IAP)
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CC[C@H](NC(=O)[C@H](C)NC)C(=O)N1C[C@@H](O)C[C@H]1Cc1c(-c2[nH]c3cc(F)ccc3c2C[C@@H]2C[C@H](O)CN2C(=O)[C@H](CC)NC(=O)[C@H](C)NC)[nH]c2cc(F)ccc12
Identifiers
PDB—
CAS-ID1260251-31-7
RxCUI—
ChEMBL IDCHEMBL3039522
ChEBI ID—
PubChem CID—
DrugBankDB11782
UNII ID6O4Z07B57R (ChemIDplus, GSRS)
Target
Agency Approved
BIRC2
BIRC2
Organism
Homo sapiens
Gene name
BIRC2
Gene synonyms
API1, MIHB, RNF48
NCBI Gene ID
329
Protein name
baculoviral IAP repeat-containing protein 2
Protein synonyms
apoptosis inhibitor 1, C-IAP1, Cellular inhibitor of apoptosis 1, hIAP-2, hIAP2, IAP homolog B, IAP-2, Inhibitor of apoptosis protein 2, NFR2-TRAF signalling complex protein, RING finger protein 48, RING-type E3 ubiquitin transferase BIRC2, TNFR2-TRAF-signaling complex protein 2
Uniprot ID
Q4TTG0
Mouse ortholog
Birc2 (11797)
baculoviral IAP repeat-containing protein 2 (Q62210)
Alternate
XIAP
XIAP
Organism
Homo sapiens
Gene name
XIAP
Gene synonyms
API3, BIRC4, IAP3
NCBI Gene ID
331
Protein name
E3 ubiquitin-protein ligase XIAP
Protein synonyms
Baculoviral IAP repeat-containing protein 4, hIAP-3, hIAP3, hILP, IAP-3, IAP-like protein, IAP-like protein 1, ILP, Inhibitor of apoptosis protein 3, RING-type E3 ubiquitin transferase XIAP, X-linked IAP, X-linked inhibitor of apoptosis protein, X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Uniprot ID
Q9NQ14
Mouse ortholog
Xiap (11798)
E3 ubiquitin-protein ligase XIAP (Q60989)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 744 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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