Benzocaine
Benzocaine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| family dollar | OTC monograph not final | 2023-06-13 |
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| burns | — | D002056 | T30.0 |
| earache | HP_0030766 | D004433 | H92.0 |
| fissure in ano | HP_0012390 | D005401 | K60.2 |
| hemorrhoids | EFO_0009552 | D006484 | K64 |
| herpes simplex | — | D006561 | B00 |
| oral ulcer | HP_0000155 | D019226 | — |
| otitis externa | EFO_0009560 | D010032 | H60 |
| otitis media | EFO_0004992 | D010033 | H66.9 |
| pruritus | HP_0000989 | D011537 | L29 |
| toothache | — | D014098 | K08.89 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
— C05: Vasoprotectives
— C05A: Agents for treatment of hemorrhoids and anal fissures for topical use
— C05AD: Local anesthetics for treatment of hemorrhoids and anal fissures for topical use
— C05AD03: Benzocaine
D: Dermatologicals
— D04: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04A: Antipruritics, incl. antihistamines, anesthetics, etc.
— D04AB: Anesthetics for topical use
— D04AB04: Benzocaine
N: Nervous system drugs
— N01: Anesthetics
— N01B: Local anesthetics
— N01BA: Esters of aminobenzoic acid for local anesthesia
— N01BA05: Benzocaine
R: Respiratory system drugs
— R02: Throat preparations
— R02A: Throat preparations
— R02AD: Local anesthetic throat preparations
— R02AD01: Benzocaine
HCPCS
No data
Clinical
Clinical Trials
89 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pharyngitis | D010612 | R07.0 | — | 1 | 5 | 1 | — | 7 | |
| Pain | D010146 | EFO_0003843 | R52 | — | 3 | 1 | 1 | 1 | 6 |
| Critical illness | D016638 | — | 1 | — | 1 | — | 2 | ||
| Postoperative pain | D010149 | G89.18 | — | — | — | 1 | 1 | 2 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | — | — | 1 | — | 1 |
| Toothache | D014098 | K08.89 | — | — | — | 1 | — | 1 | |
| Dental pins | D003772 | — | — | — | 1 | — | 1 | ||
| Dry eye syndromes | D015352 | H04.12 | — | — | — | 1 | — | 1 | |
| Analgesia | D000698 | — | — | — | 1 | — | 1 | ||
| Pneumonia | D011014 | EFO_0003106 | J18 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ischemic stroke | D000083242 | — | — | 1 | — | — | 1 | ||
| Hyperglycemia | D006943 | HP_0003074 | R73.9 | — | — | 1 | — | — | 1 |
| Eczema | D004485 | HP_0000964 | L30.9 | — | — | 1 | — | — | 1 |
| Respiratory tract diseases | D012140 | — | — | 1 | — | — | 1 | ||
| Chronic renal insufficiency | D051436 | N18 | — | — | 1 | — | — | 1 | |
| Gastroesophageal reflux | D005764 | EFO_0003948 | K21 | — | — | 1 | — | — | 1 |
| Dyspepsia | D004415 | EFO_0008533 | K30 | — | — | 1 | — | — | 1 |
| Abdominal pain | D015746 | R10.9 | — | — | 1 | — | — | 1 | |
| Malabsorption syndromes | D008286 | EFO_0009554 | K90 | — | — | 1 | — | — | 1 |
| Stomach diseases | D013272 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Parkinson disease | D010300 | EFO_0002508 | G20 | — | 3 | — | — | — | 3 |
| Local anesthesia | D000772 | — | 1 | — | — | 2 | 3 | ||
| Gaucher disease | D005776 | Orphanet_355 | E75.22 | 1 | 2 | — | — | — | 2 |
| Cough | D003371 | HP_0012735 | R05 | — | 1 | — | — | — | 1 |
| Dementia | D003704 | F03 | — | 1 | — | — | — | 1 | |
| Lewy body disease | D020961 | EFO_0006792 | G31.83 | 1 | 1 | — | — | — | 1 |
| Cerebrovascular disorders | D002561 | EFO_0003763 | I60-I69 | — | 1 | — | — | — | 1 |
| Dental anesthesia | D000766 | 1 | 1 | — | — | — | 1 | ||
| Asthma | D001249 | EFO_0000270 | J45 | — | 1 | — | — | — | 1 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | 7 | — | — | — | — | 7 | ||
| Oral lichen planus | D017676 | 1 | — | — | — | 2 | 3 | ||
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 1 | 2 |
| Oral ulcer | D019226 | HP_0000155 | 1 | — | — | — | — | 1 | |
| Staphylococcal infections | D013203 | A49.01 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Diabetic neuropathies | D003929 | EFO_1000783 | — | — | — | — | 2 | 2 | |
| Hypotension | D007022 | EFO_0005251 | I95 | — | — | — | — | 1 | 1 |
| Orthodontic anchorage procedures | D052280 | — | — | — | — | 1 | 1 | ||
| Body weight | D001835 | EFO_0004338 | — | — | — | — | 1 | 1 | |
| Glucose metabolism disorders | D044882 | — | — | — | — | 1 | 1 | ||
| Lichen planus | D008010 | L43 | — | — | — | — | 1 | 1 | |
| Weight loss | D015431 | HP_0001824 | — | — | — | — | 1 | 1 | |
| Feeding behavior | D005247 | — | — | — | — | 1 | 1 | ||
| Duchenne muscular dystrophy | D020388 | — | — | — | — | 1 | 1 | ||
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BENZOCAINE |
| INN | benzocaine |
| Description | Benzocaine is a benzoate ester having 4-aminobenzoic acid as the acid component and ethanol as the alcohol component. A surface anaesthetic, it is used to suppress the gag reflex, and as a lubricant and topical anaesthetic on the larynx, mouth, nasal cavity, respiratory tract, oesophagus, rectum, urinary tract, and vagina. It has a role as a topical anaesthetic, an antipruritic drug, an allergen and a sensitiser. It is a benzoate ester and a substituted aniline. |
| Classification | Small molecule |
| Drug class | local anesthetics |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CCOC(=O)c1ccc(N)cc1 |
Identifiers
| PDB | — |
| CAS-ID | 94-09-7 |
| RxCUI | 1399 |
| ChEMBL ID | CHEMBL278172 |
| ChEBI ID | 116735 |
| PubChem CID | 2337 |
| DrugBank | DB01086 |
| UNII ID | U3RSY48JW5 (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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2,369 adverse events reported
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