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Beloranib
Beloranib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against methionine aminopeptidase 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
8 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
ObesityD009765EFO_0001073E66.9341——8
Prader-willi syndromeD011218Orphanet_739Q87.11—11——2
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OverweightD050177E66.3—2———2
Type 2 diabetes mellitusD003924EFO_0001360E11—1———1
CraniopharyngiomaD003397—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBELORANIB
INNbeloranib
Description
Beloranib is a former drug candidate for the treatment of obesity. It was discovered by CKD Pharmaceuticals and its clinical development was led by Zafgen. Drug development was halted in 2016 after deaths during clinical trials.
Classification
Small molecule
Drug classangiogenesis inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CO[C@H]1[C@H]([C@@]2(C)O[C@@H]2CC=C(C)C)[C@]2(CC[C@H]1OC(=O)/C=C/c1ccc(OCCN(C)C)cc1)CO2
Identifiers
PDB—
CAS-ID251111-30-5
RxCUI—
ChEMBL IDCHEMBL4297504
ChEBI ID—
PubChem CID6918502
DrugBankDB12671
UNII IDFI471K8BU6 (ChemIDplus, GSRS)
Target
Agency Approved
METAP2
METAP2
Organism
Homo sapiens
Gene name
METAP2
Gene synonyms
MNPEP, P67EIF2
NCBI Gene ID
10988
Protein name
methionine aminopeptidase 2
Protein synonyms
eIF-2-associated p67 homolog, Initiation factor 2-associated 67 kDa glycoprotein, p67, p67eIF2, Peptidase M, peptidase M 2, testicular tissue protein Li 17
Uniprot ID
P50579
Mouse ortholog
Metap2 (56307)
methionine aminopeptidase 2 (O08663)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 76 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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