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Beclovent, Trimbow(beclomethasone dipropionate)
Beconase, CHF 5993 Chiesi Farmaceutici S.p.A, Qnasl, Qvar, Riarify, Trimbow, Trydonis (beclomethasone dipropionate) is a small molecule pharmaceutical. Beclomethasone dipropionate was first approved as Beclovent on 1982-01-01. It is used to treat allergic rhinitis perennial and inflammation in the USA. It has been approved in Europe to treat chronic obstructive pulmonary disease. It is known to target adhesion G protein-coupled receptor G3.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
otorhinolaryngologic diseasesD010038
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
Beconase, Qnasl, Qvar (discontinued: Beclovent, Beconase, Vancenase, Vanceril)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Beclomethasone dipropionate
Tradename
Company
Number
Date
Products
QVAR REDIHALERNorton WaterfordN-207921 RX2017-08-03
2 products, RLD
QNASLTevaN-202813 RX2012-03-23
2 products, RLD, RS
Show 7 discontinued
Beclomethasone dipropionate monohydrate
Tradename
Company
Number
Date
Products
BECONASE AQGSKN-019389 RX1987-07-27
1 products, RLD, RS
Show 2 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
beconaseNew Drug Application2021-02-09
qnaslNew Drug Application2020-02-19
qvar redihalerNew Drug Application2023-06-07
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
allergic rhinitis perennialEFO_1001417D012221J30.89
inflammationMP_0001845D007249—
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Beclomethasone Dipropionate, Qvar Redihaler, Norton Waterford
115836432041-08-19DP
115596372039-07-21DP
107924472039-01-25DP
113958882038-01-26DP
89314762031-07-17DP
81327122028-09-07DP
Beclomethasone Dipropionate, Qvar 40, Teva Branded Pharm
105618082032-01-01DP
94632892031-05-18DP
98085872031-05-18DP
100225092031-05-18DP
100225102031-05-18DP
100861562031-05-18DP
106955122031-05-18DP
113958892031-05-18DP
Beclomethasone Dipropionate, Qnasl, Teva Branded Pharm
101888112031-10-21DP
77800382027-01-24DP
ATC Codes
A: Alimentary tract and metabolism drugs
— A07: Antidiarrheals, intestinal antiinflammatory/antiinfective agents
— A07E: Intestinal antiinflammatory agents
— A07EA: Corticosteroids acting locally
— A07EA07: Beclometasone
D: Dermatologicals
— D07: Corticosteroids, dermatological preparations
— D07A: Corticosteroid dermatological preparations, plain
— D07AC: Corticosteroids, potent (group iii)
— D07AC15: Beclometasone
— D07C: Corticosteroids, combinations with antibiotics
— D07CC: Corticosteroids, potent, combinations with antibiotics
— D07CC04: Beclometasone and antibiotics
R: Respiratory system drugs
— R01: Nasal preparations
— R01A: Decongestants and other nasal preparations for topical use
— R01AD: Corticosteroid nasal preparations for topical use
— R01AD01: Beclometasone
— R03: Drugs for obstructive airway diseases
— R03A: Adrenergics, inhalants
— R03AK: Adrenergics inhalants in combination with corticosteroids or other drugs, excl. anticholinergics
— R03AK08: Formoterol and beclometasone
— R03AK13: Salbutamol and beclometasone
— R03AL: Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
— R03AL09: Formoterol, glycopyrronium bromide and beclometasone
— R03B: Other drugs for obstructive airway diseases, inhalants in atc
— R03BA: Glucocorticoid inhalants for obstructive airway disease
— R03BA01: Beclometasone
HCPCS
No data
Clinical
Clinical Trials
141 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
AsthmaD001249EFO_0000270J4531228151269
Chronic obstructive pulmonary diseaseD029424EFO_0000341J44.94—57622
Allergic rhinitis seasonalD006255EFO_0003956J301331—7
Allergic rhinitisD065631J30.91—1215
Respiratory soundsD012135HP_0010307R06.1——13—4
Disease progressionD018450——11—2
Endotracheal anesthesiaD000770———1—1
Status asthmaticusD013224———1—1
EmphysemaD004646EFO_0000464J43———1—1
Respiratory tract infectionsD012141J06.9———1—1
Show 2 more
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Graft vs host diseaseD006086D89.81122—15
Allergic rhinitis perennialD012221EFO_1001417J30.89——4—15
Bronchopulmonary dysplasiaD001997P27.8—11—13
Lung diseasesD008171EFO_0003818J98.4——2——2
BronchiectasisD001987HP_0002110J47——1——1
Respiratory tract diseasesD012140——1——1
FolliculitisD005499—11——1
CroupD003440EFO_0007227J05.0——1——1
Hyaline membrane diseaseD006819EFO_1000644P22.0——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myelodysplastic syndromesD009190D4612———2
Myeloid leukemia acuteD015470C92.0—1———1
Non-hodgkin lymphomaD008228C85.9—1———1
Essential thrombocythemiaD013920D47.3—1———1
Primary myelofibrosisD055728D47.4—1———1
Multiple myelomaD009101C90.0—1———1
Precursor cell lymphoblastic leukemia-lymphomaD054198C91.0—1———1
B-cell chronic lymphocytic leukemiaD015451C91.1—1———1
Bcr-abl positive chronic myelogenous leukemiaD015464EFO_0000340—1———1
Myelomonocytic leukemia chronicD015477C93.1—1———1
Show 32 more
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
HivD006678O98.71————1
PharmacokineticsD0105991————1
Eosinophilic esophagitisD057765EFO_0004232K20.01————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Ulcerative colitisD003093EFO_0000729K51————11
ObesityD009765EFO_0001073E66.9————11
Intraocular pressureD007429————11
Medication adherenceD055118EFO_0006344————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBECLOMETHASONE DIPROPIONATE
INNbeclometasone
Description
Beclomethasone dipropionate is a steroid ester comprising beclomethasone having propionyl groups at the 17- and 21-positions. It has a role as an anti-inflammatory drug, an anti-asthmatic drug, a prodrug and an anti-arrhythmia drug. It is a steroid ester, an enone, a 20-oxo steroid, an 11beta-hydroxy steroid, a propanoate ester, a corticosteroid, a glucocorticoid, a 3-oxo-Delta(1),Delta(4)-steroid and a chlorinated steroid. It is functionally related to a beclomethasone.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCC(=O)OCC(=O)[C@@]1(OC(=O)CC)[C@@H](C)C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@@]21C
Identifiers
PDB—
CAS-ID5534-09-8
RxCUI1348
ChEMBL IDCHEMBL1200500
ChEBI ID3002
PubChem CID21700
DrugBankDB00394
UNII IDKGZ1SLC28Z (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
ADGRG3
ADGRG3
Organism
Homo sapiens
Gene name
ADGRG3
Gene synonyms
GPR97, PGR26
NCBI Gene ID
222487
Protein name
adhesion G protein-coupled receptor G3
Protein synonyms
G protein-coupled receptor 97, G-protein coupled receptor 97, G-protein coupled receptor PGR26, probable G-protein coupled receptor 97
Uniprot ID
Q86Y34
Mouse ortholog
Adgrg3 (54672)
adhesion G protein-coupled receptor G3 (Q8R0T6)
Variants
Clinical Variant
No data
Financial
Qvar - Teva
$
€
£
₣
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 4,194 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,528 adverse events reported
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