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Duavee, Conbriza(bazedoxifene)
Conbriza, Duavee, Duavive (bazedoxifene) is a small molecule pharmaceutical. Bazedoxifene was first approved as Conbriza on 2009-04-17. It is used to treat menopause in the USA. It has been approved in Europe to treat postmenopausal osteoporosis and postmenopause. The pharmaceutical is active against estrogen receptor beta and estrogen receptor.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
musculoskeletal diseasesD009140
nutritional and metabolic diseasesD009750
reproductive and urinary physiological phenomenaD012101
Trade Name
FDA
EMA
Combinations
Duavee
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Bazedoxifene acetate
+
Estrogens
+
conjugated
Tradename
Company
Number
Date
Products
DUAVEEWYETH PHARMSN-022247 RX2013-10-03
1 products, RLD, RS
Labels
FDA
EMA
Brand Name
Status
Last Update
duaveeNew Drug Application2022-12-20
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
menopauseEFO_0003922D008593N95
Agency Specific
FDA
EMA
No data
Patent Expiration
Patent
Expires
Flag
FDA Information
Bazedoxifene Acetate / Estrogens, Conjugated, Duavee, Wyeth Pharms
76830512027-03-10DS, DPU-594, U-904
64795352024-05-06DPU-594, U-904
ATC Codes
G: Genito urinary system and sex hormones
G03: Sex hormones and modulators of the genital system
G03C: Estrogens, sex hormones and modulators of the genital system
G03CC: Estrogens, combinations with other drugs
G03CC07: Conjugated estrogens and bazedoxifene
G03X: Other sex hormones and modulators of the genital system in atc
G03XC: Selective estrogen receptor modulators
G03XC02: Bazedoxifene
HCPCS
No data
Clinical
Clinical Trials
44 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Postmenopausal osteoporosisD015663EFO_00038541113
ObesityD009765EFO_0001073E66.9112
SchizophreniaD012559EFO_0000692F2011
Psychotic disordersD011618F20.8111
DepressionD003863F33.911
Rheumatoid arthritisD001172EFO_0000685M06.911
EndometriosisD004715EFO_0001065N8011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
OsteoporosisD010024EFO_0003882M81.026210
PostmenopauseD0176984217
MenopauseD008593EFO_0003922N953115
Endometrial hyperplasiaD004714N85.022
Sleep apnea syndromesD012891EFO_0003877G47.311
Oxidative stressD018384EFO_100190511
Hot flashesD01958411
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50335
Risk reduction behaviorD04024211
AtherosclerosisD050197EFO_0003914I25.111
Cognitive dysfunctionD060825G31.8411
Multiple sclerosisD009103EFO_0003885G3511
Relapsing-remitting multiple sclerosisD020529EFO_000392911
Ductal carcinoma breastD01827011
Prediabetic stateD011236EFO_1001121R73.0311
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients44
SleepD012890GO_003043111
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Pancreatic neoplasmsD010190EFO_0003860C2511
OsteoarthritisD010003EFO_0002506M15-M1911
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameBAZEDOXIFENE
INNbazedoxifene
Description
Bazedoxifene is a phenylindole.
Classification
Small molecule
Drug classantiestrogens of the clomifene and tamoxifen groups
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cc1c(-c2ccc(O)cc2)n(Cc2ccc(OCCN3CCCCCC3)cc2)c2ccc(O)cc12
Identifiers
PDB4XI3
CAS-ID198481-32-2
RxCUI1441386
ChEMBL IDCHEMBL46740
ChEBI ID
PubChem CID154257
DrugBankDB06401
UNII IDQ16TT9C5BK (ChemIDplus, GSRS)
Target
Agency Approved
ESR2
ESR2
ESR1
ESR1
Organism
Homo sapiens
Gene name
ESR2
Gene synonyms
ESTRB, NR3A2
NCBI Gene ID
Protein name
estrogen receptor beta
Protein synonyms
estrogen receptor beta 2, estrogen receptor beta 4, Nuclear receptor subfamily 3 group A member 2, oestrogen receptor beta
Uniprot ID
Mouse ortholog
Esr2 (13983)
estrogen receptor beta (O08537)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,383 documents
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Safety
Black-box Warning
Black-box warning for: Duavee
Adverse Events
Top Adverse Reactions
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6,198 adverse events reported
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