Bardoxolone
Bardoxolone is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target peroxisome proliferator-activated receptor gamma and kelch-like ECH-associated protein 1.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
28 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Chronic renal insufficiency | D051436 | N18 | 3 | 4 | 2 | — | — | 9 | |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 3 | 4 | 1 | — | — | 8 |
| Diabetic nephropathies | D003928 | EFO_0000401 | — | 2 | 1 | — | — | 3 | |
| Autosomal dominant polycystic kidney | D016891 | EFO_1001496 | Q61.2 | — | 1 | 2 | — | — | 3 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | — | 1 | 1 | — | — | 2 |
| Hereditary nephritis | D009394 | EFO_0004128 | Q87.81 | — | 1 | 2 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sarcoidosis | D012507 | EFO_0000690 | D80-D89 | — | 1 | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | — | 1 | — | — | — | 1 | ||
| Idiopathic pulmonary fibrosis | D054990 | J84.112 | — | 1 | — | — | — | 1 | |
| Interstitial lung diseases | D017563 | EFO_0004244 | J84.89 | — | 1 | — | — | — | 1 |
| Cryptogenic organizing pneumonia | D018549 | EFO_1001300 | J84.116 | — | 1 | — | — | — | 1 |
| Idiopathic interstitial pneumonias | D054988 | — | 1 | — | — | — | 1 | ||
| Hamman-rich syndrome | D000080203 | J84.11 | — | 1 | — | — | — | 1 | |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | — | 1 | |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | 1 | — | — | — | 1 | |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | — | 1 | — | — | — | 1 |
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BARDOXOLONE |
| INN | bardoxolone |
| Description | Bardoxolone methyl is a member of cyclohexenones. |
| Classification | Small molecule |
| Drug class | steroids (not prednisolone derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](C(=O)C=C4[C@@]3(C)CC[C@H]3C(C)(C)C(=O)C(C#N)=C[C@]43C)[C@@H]2C1 |
Identifiers
| PDB | — |
| CAS-ID | 218600-44-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1093059 |
| ChEBI ID | — |
| PubChem CID | 400769 |
| DrugBank | DB12651 |
| UNII ID | 7HT68L8941 (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PPARG
PPARG
KEAP1
KEAP1
Organism
Homo sapiens
Gene name
PPARG
Gene synonyms
NR1C3
NCBI Gene ID
Protein name
peroxisome proliferator-activated receptor gamma
Protein synonyms
Nuclear receptor subfamily 1 group C member 3, peroxisome proliferator-activated receptor-gamma 5, peroxisome proliferator-activated receptor-gamma splicing, PPAR-gamma
Uniprot ID
Mouse ortholog
Pparg (19016)
peroxisome proliferator-activated receptor gamma (P37238)
Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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