Bafetinib
Bafetinib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against tyrosine-protein kinase ABL1 and tyrosine-protein kinase Lyn.
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Therapeutic Areas
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Trade Name
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Drug Products
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EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
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Indications
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Agency Specific
FDA
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Patent Expiration
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ATC Codes
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HCPCS
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Clinical
Clinical Trials
4 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 1 | — | — | — | — | 1 | |
| Bcr-abl positive chronic myelogenous leukemia | D015464 | EFO_0000340 | 1 | — | — | — | — | 1 | |
| Brain neoplasms | D001932 | EFO_0003833 | C71 | 1 | — | — | — | — | 1 |
| Neoplasms | D009369 | C80 | 1 | — | — | — | — | 1 | |
| Glioblastoma | D005909 | EFO_0000515 | 1 | — | — | — | — | 1 | |
| Glioma | D005910 | EFO_0000520 | 1 | — | — | — | — | 1 | |
| Gliosarcoma | D018316 | 1 | — | — | — | — | 1 | ||
| Ependymoma | D004806 | 1 | — | — | — | — | 1 | ||
| Astrocytoma | D001254 | EFO_0000271 | 1 | — | — | — | — | 1 | |
| Oligodendroglioma | D009837 | EFO_0000631 | 1 | — | — | — | — | 1 |
Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | BAFETINIB |
| INN | bafetinib |
| Description | Bafetinib (NS-187) is an experimental cancer drug developed by Nippon Shinyaku and licensed to CytRx. It is an inhibitor of Lyn and Bcr-Abl. It reached phase II clinical trials in 2010.
|
| Classification | Small molecule |
| Drug class | tyrosine kinase inhibitors |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1ccc(NC(=O)c2ccc(CN3CC[C@H](N(C)C)C3)c(C(F)(F)F)c2)cc1Nc1nccc(-c2cncnc2)n1 |
Identifiers
| PDB | 2E2B |
| CAS-ID | 859212-16-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL206834 |
| ChEBI ID | — |
| PubChem CID | 11387605 |
| DrugBank | DB11851 |
| UNII ID | NVW4Z03I9B (ChemIDplus, GSRS) |
Target
Agency Approved
ABL1
ABL1
LYN
LYN
Organism
Homo sapiens
Gene name
ABL1
Gene synonyms
ABL, JTK7
NCBI Gene ID
Protein name
tyrosine-protein kinase ABL1
Protein synonyms
Abelson murine leukemia viral oncogene homolog 1, Abelson tyrosine-protein kinase 1, ABL protooncogene 1 nonreceptor tyrosine kinase, BCR-ABL1 p190, BCR/ABL e8a2 fusion, BCR/ABL1 e1a2 fusion protein, bcr/c-abl oncogene protein, c-abl oncogene 1, receptor tyrosine kinase, p150, Proto-oncogene c-Abl, proto-oncogene tyrosine-protein kinase ABL1, v-abl Abelson murine leukemia viral oncogene homolog 1
Uniprot ID
Mouse ortholog
Abl1 (11350)
tyrosine-protein kinase ABL1 (P00520)
Alternate
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Variants
Clinical Variant
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Financial
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Trends
PubMed Central
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Additional graphs summarizing 243 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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4 adverse events reported
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