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Aprotinin
Trasylol (aprotinin) is an unknown pharmaceutical. Aprotinin was first approved as Trasylol on 1993-12-29. It is used to treat hemorrhage in the USA. The pharmaceutical is active against plasminogen.
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COVID-19
Commercial
Therapeutic Areas
Therapeutic Area
MeSH
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
Reference product - 351(a)
Reference product - 351(a)
Interchangeable product - 351(k)
Interchangeable product - 351(k)
Biosimilar product - 351(k)
Biosimilar product - 351(k)
Aprotinin
Tradename
Proper name
Company
Number
Date
Products
TrasylolaprotininBayer HealthCare Pharmaceuticals Inc.N-20304 DISCN1993-12-29
2 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
hemorrhageMP_0001914D006470R58
Agency Specific
FDA
EMA
Expiration
Code
aprotinin, Trasylol, Bayer HealthCare Pharmaceuticals Inc.
2100-12-29Orphan excl.
Patent Expiration
No data
ATC Codes
B: Blood and blood forming organ drugs
— B02: Antihemorrhagics
— B02A: Antifibrinolytics
— B02AB: Proteinase inhibitors, antifibrinolytic
— B02AB01: Aprotinin
HCPCS
No data
Clinical
Clinical Trials
19 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Surgical blood lossD016063——4——4
Postoperative hemorrhageD019106——2—13
HemorrhageD006470MP_0001914R58——1——1
Coronary artery bypassD001026EFO_0003776——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
InfectionsD007239EFO_0000544—1———1
GallstonesD042882EFO_0004210—1———1
Pathologic processesD010335—1———1
Rectal neoplasmsD012004—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PancreatitisD010195EFO_0000278K851————1
Breast neoplasmsD001943EFO_0003869C501————1
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Covid-19D000086382U07.1————11
Coronary artery diseaseD003324I25.1————11
Myocardial ischemiaD017202EFO_1001375I20-I25————11
Angina pectorisD000787EFO_0003913I20————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAPROTININ
INNaprotinin
Description
Pancreatic trypsin inhibitor precursor (Basic protease inhibitor) (BPI)
Classification
Protein
Drug class—
Image (chem structure or protein)APROTININ
Structure (InChI/SMILES or Protein Sequence)—
Identifiers
PDB1B0C, 1EAW, 1EJM, 1G6X, 1OA5, 1OA6, 1P2I, 1P2J, 1P2K, 1P2M, 1P2N, 1P2O, 1P2Q, 1QLQ, 1T7C, 1T8L, 1T8M, 1T8N, 1T8O, 1UUA, 1UUB, 1YKT, 1YLC, 1YLD, 2FI3, 2FI4, 2FI5, 2FTL, 2FTM, 2IJO, 2R9P, 2RA3, 2TPI, 2ZJX, 2ZVX, 3FP6, 3FP7, 3FP8, 3GYM, 3LDI, 3LDJ, 3LDM, 3OTJ, 3P92, 3P95, 3U1J, 4BNR, 4DG4, 4WWY, 4WXV, 4Y0Y, 4Y0Z, 4Y10, 4Y11, 5JB4, 5JB5, 5JB6, 5JB7, 5XX2, 5XX3, 5XX4, 5XX5, 5XX6, 5XX7, 5XX8, 5YVU, 6F1F, 7PH1, 7QIQ, 7QIR, 7QIS, 7QIT
CAS-ID9087-70-1
RxCUI1056
ChEMBL IDCHEMBL1201619
ChEBI ID—
PubChem CID—
DrugBankDB06692
UNII ID04XPW8C0FL (ChemIDplus, GSRS)
Target
Agency Approved
PLG
PLG
Organism
Homo sapiens
Gene name
PLG
Gene synonyms
NCBI Gene ID
5340
Protein name
plasminogen
Protein synonyms
plasmin
Uniprot ID
Q6PA00
Mouse ortholog
Plg (18815)
plasminogen (Q91WJ5)
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
Mock data
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Additional graphs summarizing 69,562 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
Mock data
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4,660 adverse events reported
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