Apilimod
Apilimod is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target 1-phosphatidylinositol 3-phosphate 5-kinase.
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Commercial
Therapeutic Areas
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Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
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Indications
FDA
EMA
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
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HCPCS
No data
Clinical
Clinical Trials
7 clinical trials
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Indications Phases 4
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Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Crohn disease | D003424 | EFO_0000384 | K50 | 1 | 4 | — | — | — | 4 |
| Covid-19 | D000086382 | U07.1 | — | 1 | — | — | — | 1 | |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | 1 | — | — | — | — | 1 |
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | APILIMOD |
| INN | apilimod |
| Description | Apilimod (STA-5326) is a drug that was initially identified as an inhibitor of production of the interleukins IL-12 and IL-23, and developed for the oral treatment of autoimmune conditions such as Crohn's disease and rheumatoid arthritis, though clinical trial results were disappointing and development for these applications was not continued.
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| Classification | Small molecule |
| Drug class | immunomodulators |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Cc1cccc(/C=N/Nc2cc(N3CCOCC3)nc(OCCc3ccccn3)n2)c1 |
Identifiers
| PDB | — |
| CAS-ID | 541550-19-0 |
| RxCUI | — |
| ChEMBL ID | CHEMBL4297643 |
| ChEBI ID | — |
| PubChem CID | 10173277 |
| DrugBank | DB05611 |
| UNII ID | GFW2K84S4L (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
PIKFYVE
PIKFYVE
Organism
Homo sapiens
Gene name
PIKFYVE
Gene synonyms
KIAA0981, PIP5K3
NCBI Gene ID
Protein name
1-phosphatidylinositol 3-phosphate 5-kinase
Protein synonyms
epididymis luminal protein 37, FYVE finger-containing phosphoinositide kinase, Phosphatidylinositol 3-phosphate 5-kinase type III, phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III, phosphoinositide kinase, FYVE finger containing, PIKfyve, PIPkin-III, Serine-protein kinase PIKFYVE, Type III PIP kinase, zinc finger, FYVE domain containing 29
Uniprot ID
Mouse ortholog
Pikfyve (18711)
1-phosphatidylinositol 3-phosphate 5-kinase (Q9Z1T6)
Variants
Clinical Variant
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Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 447 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
0 adverse events reported
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