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Amsacrine
Amsacrine is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XX: Other antineoplastic agents in atc
— L01XX01: Amsacrine
HCPCS
No data
Clinical
Clinical Trials
9 clinical trials
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Myeloid leukemia acuteD015470C92.0——11—2
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
LeukemiaD007938C95125——6
NeutropeniaD009503D70——2——2
Myelodysplastic syndromesD009190D46——1——1
Indications Phases 2
No data
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMSACRINE
INNamsacrine
Description
Amsacrine is a sulfonamide that is N-phenylmethanesulfonamide substituted by a methoxy group at position 3 and an acridin-9-ylamino group at position 4. It exhibits antineoplastic activity. It has a role as an antineoplastic agent and an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor. It is a sulfonamide, a member of acridines and an aromatic ether.
Classification
Small molecule
Drug classacridine derivatives
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(NS(C)(=O)=O)ccc1Nc1c2ccccc2nc2ccccc12
Identifiers
PDB—
CAS-ID51264-14-3
RxCUI739
ChEMBL IDCHEMBL43
ChEBI ID2687
PubChem CID2179
DrugBankDB00276
UNII ID00DPD30SOY (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,253 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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527 adverse events reported
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