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Aminophylline
Aminophyllin, Phyllocontin, Somophyllin, Truphylline (aminophylline) is a small molecule pharmaceutical. Aminophylline was first approved as Aminophyllin on 1982-01-01. It is used to treat apnea, asthma, bradycardia, bronchial spasm, and bronchitis amongst others in the USA. The pharmaceutical is active against adenosine receptor A2b and adenosine receptor A2a. In addition, it is known to target adenosine receptor A1 and adenosine receptor A3.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
infectionsD007239
respiratory tract diseasesD012140
cardiovascular diseasesD002318
immune system diseasesD007154
signs and symptoms pathological conditionsD013568
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Aminophylline
Tradename
Company
Number
Date
Products
SOMOPHYLLINFisonsN-018232 DISCN1982-04-02
1 products
AMINOPHYLLING.D. SearleN-002386 DISCN1982-01-01
2 products
AMINOPHYLLINE IN SODIUM CHLORIDE 0.45% IN PLASTIC CONTAINERHospiraN-018924 DISCN1984-12-12
4 products
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Labels
FDA
EMA
No data
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
apneaHP_0002104D001049R06.81
asthmaEFO_0000270D001249J45
bradycardiaHP_0001662D001919R00.1
bronchial spasm—D001986—
bronchitis—D001991J40
pulmonary emphysema—D011656J43
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03D: Other systemic drugs for obstructive airway diseases in atc
— R03DA: Xanthines, systemic for obstructive airway disease
— R03DA05: Aminophylline
— R03DA55: Aminophylline, combinations
— R03DB: Xanthines and adrenergics
— R03DB05: Aminophylline and adrenergics
HCPCS
No data
Clinical
Clinical Trials
2 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C50——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Prostatic neoplasmsD011471C61—1———1
Indications Phases 1
No data
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMINOPHYLLINE
INNaminophylline
Description
Aminophylline is a mixture comprising of theophylline and ethylenediamine in a 2:1 ratio. It has a role as a bronchodilator agent and a cardiotonic drug. It contains a theophylline and an ethylenediamine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Cn1c(=O)c2[nH]cnc2n(C)c1=O.Cn1c(=O)c2[nH]cnc2n(C)c1=O.NCCN
Identifiers
PDB—
CAS-ID317-34-0
RxCUI689
ChEMBL IDCHEMBL1370561
ChEBI ID—
PubChem CID9433
DrugBankDB01223
UNII ID27Y3KJK423 (ChemIDplus, GSRS)
Target
Agency Approved
ADORA2B
ADORA2B
ADORA2A
ADORA2A
Organism
Homo sapiens
Gene name
ADORA2B
Gene synonyms
NCBI Gene ID
136
Protein name
adenosine receptor A2b
Protein synonyms
Uniprot ID
P29275
Mouse ortholog
Adora2b (11541)
adenosine receptor A2b (Q8BXI2)
Alternate
ADORA1
ADORA1
ADORA3
ADORA3
Organism
Homo sapiens
Gene name
ADORA1
Gene synonyms
NCBI Gene ID
134
Protein name
adenosine receptor A1
Protein synonyms
Uniprot ID
Q8TAM8
Mouse ortholog
Adora1 (11539)
adenosine receptor A1 (Q9WUF9)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 386 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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8 adverse events reported
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