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Ambroxol
Ambroxol is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target lysosomal acid glucosylceramidase.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
R: Respiratory system drugs
— R03: Drugs for obstructive airway diseases
— R03C: Adrenergics for systemic use
— R03CC: Selective beta-2-adrenoreceptor agonists, systemic
— R03CC63: Clenbuterol and ambroxol
— R05: Cough and cold preparations
— R05C: Expectorants, excl. combinations with cough suppressants
— R05CB: Mucolytics
— R05CB06: Ambroxol
HCPCS
No data
Clinical
Clinical Trials
28 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Critical illnessD016638———1—1
PneumoniaD011014EFO_0003106J18———1—1
Healthcare-associated pneumoniaD000077299———1—1
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
PharyngitisD010612R07.0—14——5
Respiratory tract diseasesD012140——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Parkinson diseaseD010300EFO_0002508G20—3———3
Gaucher diseaseD005776Orphanet_355E75.2212———2
CoughD003371HP_0012735R05—1———1
DementiaD003704F03—1———1
Lewy body diseaseD020961EFO_0006792G31.8311———1
PainD010146EFO_0003843R52—1———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—7————7
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Diabetic neuropathiesD003929EFO_1000783————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameAMBROXOL
INNambroxol
Description
Ambroxol is an aromatic amine.
Classification
Small molecule
Drug class—
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
Nc1c(Br)cc(Br)cc1CN[C@H]1CC[C@H](O)CC1
Identifiers
PDB—
CAS-ID18683-91-5
RxCUI625
ChEMBL IDCHEMBL153479
ChEBI ID—
PubChem CID2132
DrugBankDB06742
UNII ID200168S0CL (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
GBA1
GBA1
Organism
Homo sapiens
Gene name
GBA1
Gene synonyms
GBA, GC, GLUC
NCBI Gene ID
2629
Protein name
lysosomal acid glucosylceramidase
Protein synonyms
Acid beta-glucosidase, Alglucerase, Beta-GC, Beta-glucocerebrosidase, Beta-glucosylceramidase 1, Cholesterol glucosyltransferase, Cholesteryl-beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, glucocerebrosidase, glucosidase, beta, acid, Glucosylceramidase beta 1, glucosylceramidase-like protein, Imiglucerase, lysosomal acid GCase, Lysosomal cholesterol glycosyltransferase, Lysosomal galactosylceramidase, lysosomal glucocerebrosidase, Lysosomal glycosylceramidase, SGTase
Uniprot ID
Q9UMJ8
Mouse ortholog
Gba1 (14466)
lysosomal acid glucosylceramidase (Q78NR7)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,961 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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592 adverse events reported
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