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Alprostadil
Caverject, Edex, Muse, Prostin (alprostadil) is a small molecule pharmaceutical. Alprostadil was first approved as Prostin vr pediatric on 1982-01-01. It is used to treat aortic arch syndromes, aortic coarctation, hypoplastic left heart syndrome, patent ductus arteriosus, and pulmonary hypertension amongst others in the USA. The pharmaceutical is active against prostaglandin E2 receptor EP1 subtype and prostaglandin E2 receptor EP2 subtype. In addition, it is known to target cation channel sperm-associated protein 4, cation channel sperm-associated protein 3, prostacyclin receptor, cation channel sperm-associated protein 2, cation channel sperm-associated protein 1, prostaglandin D2 receptor, prostaglandin E2 receptor EP4 subtype, and prostaglandin E2 receptor EP3 subtype.
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Commercial
Therapeutic Areas
Therapeutic Area
MeSH
respiratory tract diseasesD012140
urogenital diseasesD000091642
cardiovascular diseasesD002318
hereditary congenital and neonatal diseases and abnormalitiesD009358
Trade Name
FDA
EMA
Caverject, Edex, Muse, Prostin (generic drugs available since 1998-01-20)
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alprostadil
Tradename
Company
Number
Date
Products
EDEXAuxilium PharmaceuticalsN-020649 RX1997-06-12
6 products, RLD, RS
MUSEMylanN-020700 RX1996-11-19
3 products, RLD, RS
PROSTIN VR PEDIATRICMylanN-018484 RX1982-01-01
1 products, RLD, RS
CAVERJECTMylanN-020379 RX1995-07-06
3 products, RLD, RS
CAVERJECT IMPULSEMylanN-021212 RX2002-06-11
2 products
Show 4 discontinued
Labels
FDA
EMA
Brand Name
Status
Last Update
caverjectNew Drug Application2023-03-24
edexNew Drug Application2018-08-22
prostin New Drug Application2022-10-03
Indications
FDA
EMA
Indication
Ontology
MeSH
ICD-10
aortic arch syndromesD001015
aortic coarctationEFO_1001267D001017Q25.1
hypoplastic left heart syndromeD018636Q23.4
patent ductus arteriosusHP_0001643D004374Q25.0
pulmonary hypertensionEFO_0001361D006976I27.20
pulmonary valve stenosisEFO_1001138D011666
tetralogy of fallotHP_0001636D013771Q21.3
tricuspid atresiaD018785
vasculogenic impotenceEFO_1001234D018783
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
C: Cardiovascular system drugs
C01: Cardiac therapy drugs
C01E: Other cardiac preparations in atc
C01EA: Prostaglandin cardiac therapy preparations
C01EA01: Alprostadil
G: Genito urinary system and sex hormones
G04: Urologicals
G04B: Urologicals
G04BE: Drugs used in erectile dysfunction
G04BE01: Alprostadil
HCPCS
Code
Description
J0270
Injection, alprostadil, 1.25 mcg (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
J0275
Alprostadil urethral suppository (code may be used for medicare when drug administered under the direct supervision of a physician, not for use when drug is self administered)
Clinical
Clinical Trials
19 clinical trials
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Mock data
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Indications Phases 4
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Atopic dermatitisD003876EFO_0000274L2011
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
EczemaD004485HP_0000964L30.944
Hand dermatosesD00622933
Male breast neoplasmsD01856711
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Hepatic insufficiencyD0485501112
Hiv infectionsD015658EFO_0000764B20112
Kaposi sarcomaD012514C46112
Lichen planusD008010L4311
Cutaneous lupus erythematosusD008178EFO_0003834L93.111
PsoriasisD011565EFO_0000676L4011
TuberculosisD014376EFO_0000774A15-A1911
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5011
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALPROSTADIL
INNalprostadil
Description
Prostaglandin E1 is a prostaglandins E. It has a role as a platelet aggregation inhibitor, a vasodilator agent, an anticoagulant and a human metabolite. It is a conjugate acid of a prostaglandin E1(1-).
Classification
Small molecule
Drug classvasodilators (undefined group); prostaglandins
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)CC(=O)[C@@H]1CCCCCCC(=O)O
Identifiers
PDB
CAS-ID745-65-3
RxCUI598
ChEMBL IDCHEMBL495
ChEBI ID15544
PubChem CID5280723
DrugBankDB00770
UNII IDF5TD010360 (ChemIDplus, GSRS)
Target
Agency Approved
PTGER1
PTGER1
PTGER2
PTGER2
Organism
Homo sapiens
Gene name
PTGER1
Gene synonyms
NCBI Gene ID
Protein name
prostaglandin E2 receptor EP1 subtype
Protein synonyms
PGE receptor, EP1 subtype, PGE2 receptor EP1 subtype, prostaglandin E receptor 1 (subtype EP1), 42kD, prostaglandin E receptor 1 (subtype EP1), 42kDa, prostaglandin E receptor 1, subtype EP1, Prostanoid EP1 receptor
Uniprot ID
Mouse ortholog
Ptger1 (19216)
prostaglandin E2 receptor EP1 subtype (P35375)
Alternate
CATSPER4
CATSPER4
CATSPER3
CATSPER3
PTGIR
PTGIR
CATSPER2
CATSPER2
CATSPER1
CATSPER1
PTGDR
PTGDR
PTGER4
PTGER4
PTGER3
PTGER3
Organism
Homo sapiens
Gene name
CATSPER4
Gene synonyms
NCBI Gene ID
Protein name
cation channel sperm-associated protein 4
Protein synonyms
ion channel CatSper4
Uniprot ID
Mouse ortholog
Catsper4 (329954)
cation channel sperm-associated protein 4 (Q8BVN3)
Variants
Clinical Variant
No data
Financial
Edex - Auxilium Pharmaceuticals
$
£
Mock data
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Tabular view
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 2,311 documents
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Safety
Black-box Warning
Black-box warning for: Prostin
Adverse Events
Top Adverse Reactions
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63 adverse events reported
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