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Almorexant
Almorexant is a small molecule pharmaceutical. It is currently being investigated in clinical studies. It is known to target orexin/Hypocretin receptor type 1 and orexin receptor type 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
6 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Sleep initiation and maintenance disordersD007319F51.011—1——2
Indications Phases 2
No data
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Healthy volunteers/patients—1———12
PharmacokineticsD0105991————1
Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALMOREXANT
INNalmorexant
Description
Almorexant is a member of isoquinolines.
Classification
Small molecule
Drug classOrexin antagonist
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CNC(=O)[C@@H](c1ccccc1)N1CCc2cc(OC)c(OC)cc2[C@@H]1CCc1ccc(C(F)(F)F)cc1
Identifiers
PDB—
CAS-ID871224-64-5
RxCUI—
ChEMBL IDCHEMBL455136
ChEBI ID—
PubChem CID23727689
DrugBankDB06673
UNII ID9KCW39P2EI (ChemIDplus, GSRS)
Target
Agency Approved
No data
Alternate
HCRTR1
HCRTR1
HCRTR2
HCRTR2
Organism
Homo sapiens
Gene name
HCRTR1
Gene synonyms
NCBI Gene ID
3061
Protein name
orexin/Hypocretin receptor type 1
Protein synonyms
hypocretin (orexin) receptor 1, Hypocretin receptor type 1, orexin receptor 1, Orexin receptor type 1, Ox-1-R, Ox1-R, Ox1R
Uniprot ID
Q9HBV6
Mouse ortholog
Hcrtr1 (230777)
orexin/Hypocretin receptor type 1 (Q80T45)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 395 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1 adverse events reported
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