Panretin(alitretinoin)
Panretin (alitretinoin) is a small molecule pharmaceutical. Alitretinoin was first approved as Panretin on 1999-02-02. It is used to treat kaposi sarcoma and skin diseases in the USA. It has been approved in Europe to treat kaposi sarcoma. The pharmaceutical is active against vitamin K epoxide reductase complex subunit 1, retinoic acid receptor gamma, retinoic acid receptor beta, and retinoic acid receptor alpha. In addition, it is known to target retinoic acid receptor RXR-alpha, retinoic acid receptor RXR-gamma, and retinoic acid receptor RXR-beta.
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Commercial
Trade Name
FDA
EMA
Panretin
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alitretinoin
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| PANRETIN | Concordia Laboratories | N-020886 RX | 1999-02-02 | 1 products, RLD, RS |
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| panretin | New Drug Application | 2020-10-09 |
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
D: Dermatologicals
— D11: Other dermatological preparations in atc
— D11A: Other dermatological preparations in atc
— D11AH: Agents for dermatitis, excluding corticosteroids
— D11AH04: Alitretinoin
L: Antineoplastic and immunomodulating agents
— L01: Antineoplastic agents
— L01X: Other antineoplastic agents in atc
— L01XF: Retinoids for cancer treatment
— L01XF02: Alitretinoin
HCPCS
No data
Clinical
Clinical Trials
535 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Melanoma | D008545 | 50 | 100 | 7 | 2 | 2 | 138 | ||
| Kidney neoplasms | D007680 | EFO_0003865 | C64 | 14 | 27 | 6 | 1 | 1 | 42 |
| Renal cell carcinoma | D002292 | 8 | 14 | 2 | 1 | — | 21 | ||
| Chronic hepatitis b | D019694 | EFO_0004197 | B18.1 | — | — | — | 1 | — | 1 |
| Hiv | D006678 | O98.7 | — | — | — | 1 | — | 1 | |
| Pulmonary tuberculosis | D014397 | EFO_1000049 | A15 | — | — | — | 1 | — | 1 |
| Liver diseases | D008107 | EFO_0001421 | K70-K77 | — | — | — | 1 | — | 1 |
| Transplantation | D014180 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 17 | 20 | 5 | — | 10 | 51 |
| Neoplasms | D009369 | C80 | 33 | 21 | 1 | — | — | 45 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 16 | 18 | 1 | — | 1 | 30 |
| Leukemia | D007938 | C95 | 12 | 16 | 4 | — | 1 | 28 | |
| Lymphoma | D008223 | C85.9 | 14 | 12 | 2 | — | — | 23 | |
| Myeloid leukemia acute | D015470 | C92.0 | 9 | 16 | 2 | — | 1 | 21 | |
| Neuroblastoma | D009447 | EFO_0000621 | 11 | 9 | 3 | — | — | 20 | |
| Myelodysplastic syndromes | D009190 | D46 | 8 | 10 | 2 | — | — | 17 | |
| Skin neoplasms | D012878 | EFO_0004198 | C44 | 1 | 11 | 1 | — | — | 13 |
| Non-hodgkin lymphoma | D008228 | C85.9 | 4 | 8 | 2 | — | — | 11 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 15 | 18 | — | — | — | 25 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 10 | 11 | — | — | — | 14 |
| Lung neoplasms | D008175 | C34.90 | 7 | 6 | — | — | 1 | 12 | |
| Non-small-cell lung carcinoma | D002289 | 7 | 9 | — | — | — | 11 | ||
| Colorectal neoplasms | D015179 | 6 | 8 | — | — | — | 11 | ||
| Stomach neoplasms | D013274 | EFO_0003897 | C16 | 8 | 5 | — | — | — | 9 |
| Sarcoma | D012509 | 6 | 4 | — | — | — | 9 | ||
| Uterine cervical neoplasms | D002583 | 7 | 7 | — | — | — | 9 | ||
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 5 | 8 | — | — | — | 8 |
| Fallopian tube neoplasms | D005185 | 4 | 2 | — | — | — | 6 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hepatitis c | D006526 | B19.2 | 1 | — | — | — | 1 | 2 | |
| B-cell lymphoma marginal zone | D018442 | C88.4 | 2 | — | — | — | — | 2 | |
| Mantle-cell lymphoma | D020522 | C83.1 | 2 | — | — | — | — | 2 | |
| Bone neoplasms | D001859 | EFO_0003820 | D16 | 2 | — | — | — | — | 2 |
| Ependymoma | D004806 | 1 | — | — | — | — | 1 | ||
| Astrocytoma | D001254 | EFO_0000271 | 1 | — | — | — | — | 1 | |
| Oligodendroglioma | D009837 | EFO_0000631 | 1 | — | — | — | — | 1 | |
| Primitive neuroectodermal tumors | D018242 | 1 | — | — | — | — | 1 | ||
| Digestive system neoplasms | D004067 | 1 | — | — | — | — | 1 | ||
| Myelodysplastic-myeloproliferative diseases | D054437 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Malignant pleural effusion | D016066 | J91.0 | — | — | — | — | 1 | 1 | |
| Beta-thalassemia | D017086 | Orphanet_848 | D56.1 | — | — | — | — | 1 | 1 |
| Common variable immunodeficiency | D017074 | EFO_0000367 | D83 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ALITRETINOIN |
| INN | alitretinoin |
| Description | 9-cis-retinoic acid is a retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry. It has a role as an antineoplastic agent, a retinoid X receptor agonist, a metabolite and a keratolytic drug. It is a conjugate acid of a 9-cis-retinoate. |
| Classification | Small molecule |
| Drug class | retinol derivatives |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CC1=C(/C=C/C(C)=C\C=C\C(C)=C\C(=O)O)C(C)(C)CCC1 |
Target
Agency Approved
VKORC1
VKORC1
RARG
RARG
RARB
RARB
RARA
RARA
Organism
Homo sapiens
Gene name
VKORC1
Gene synonyms
VKOR
NCBI Gene ID
Protein name
vitamin K epoxide reductase complex subunit 1
Protein synonyms
phylloquinone epoxide reductase, vitamin K dependent clotting factors deficiency 2, Vitamin K1 2,3-epoxide reductase subunit 1, vitamin K1 epoxide reductase (warfarin-sensitive)
Uniprot ID
Mouse ortholog
Vkorc1 (27973)
vitamin K epoxide reductase complex subunit 1 (Q9CRC0)
Alternate
RXRA
RXRA
RXRG
RXRG
RXRB
RXRB
Organism
Homo sapiens
Gene name
RXRA
Gene synonyms
NR2B1
NCBI Gene ID
Protein name
retinoic acid receptor RXR-alpha
Protein synonyms
Nuclear receptor subfamily 2 group B member 1, retinoid X nuclear receptor alpha, Retinoid X receptor alpha
Uniprot ID
Mouse ortholog
Rxra (20181)
retinoic acid receptor RXR-alpha (P28700)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 627 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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1,383 adverse events reported
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