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Alisertib
Alisertib is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against aurora kinase A. In addition, it is known to target ephrin type-A receptor 2.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
No data
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
60 clinical trials
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Mock data
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
T-cell lymphoma peripheralD016411C84.9——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Breast neoplasmsD001943EFO_0003869C5044———7
Mantle-cell lymphomaD020522C83.143———6
Large b-cell lymphoma diffuseD016403C83.343———6
Burkitt lymphomaD002051C83.743———6
Non-hodgkin lymphomaD008228C85.931———4
Follicular lymphomaD008224C8231———4
Myeloid leukemia acuteD015470C92.013———4
Prostatic neoplasmsD011471C6121——13
Non-small-cell lung carcinomaD00228932———3
NeuroblastomaD009447EFO_000062122———3
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Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C8017————17
LymphomaD008223C85.95————5
Head and neck neoplasmsD0062582————2
Pancreatic neoplasmsD010190EFO_0003860C252————2
B-cell chronic lymphocytic leukemiaD015451C91.12————2
Mucinous adenocarcinomaD0022881————1
Colonic neoplasmsD003110C181————1
Rectal neoplasmsD0120041————1
Urogenital neoplasmsD014565EFO_0003863D071————1
MelanomaD0085451————1
Show 15 more
Indications Without Phase
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Primary myelofibrosisD055728D47.4————11
Megakaryoblastic leukemia acuteD007947C94.2————11
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameALISERTIB
INNalisertib
Description
4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxybenzoic acid is a benzazepine.
Classification
Small molecule
Drug classserine/threonine kinase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
COc1cc(Nc2ncc3c(n2)-c2ccc(Cl)cc2C(c2c(F)cccc2OC)=NC3)ccc1C(=O)O
Identifiers
PDB5IA0
CAS-ID1028486-01-2
RxCUI—
ChEMBL IDCHEMBL483158
ChEBI ID—
PubChem CID24771867
DrugBankDB05220
UNII IDT66ES73M18 (ChemIDplus, GSRS)
Target
Agency Approved
AURKA
AURKA
Organism
Homo sapiens
Gene name
AURKA
Gene synonyms
AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
NCBI Gene ID
6790
Protein name
aurora kinase A
Protein synonyms
ARK-1, Aurora 2, Aurora-related kinase 1, aurora/IPL1-like kinase, Aurora/IPL1-related kinase 1, Breast tumor-amplified kinase, Ipl1- and aurora-related kinase 1, protein phosphatase 1, regulatory subunit 47, serine/threonine protein kinase 15, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase Ayk1
Uniprot ID
Q9UPG5
Mouse ortholog
Aurka (20878)
aurora kinase A (Q91YU4)
Alternate
EPHA2
EPHA2
Organism
Homo sapiens
Gene name
EPHA2
Gene synonyms
ECK
NCBI Gene ID
1969
Protein name
ephrin type-A receptor 2
Protein synonyms
Epithelial cell kinase, epithelial cell receptor protein tyrosine kinase, Tyrosine-protein kinase receptor ECK
Uniprot ID
Q8N3Z2
Mouse ortholog
Epha2 (13836)
ephrin type-A receptor 2 (Q62212)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 1,715 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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72 adverse events reported
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