Alatrofloxacin mesylate
Trovan (alatrofloxacin mesylate) is a small molecule pharmaceutical. Alatrofloxacin mesylate was first approved as Trovan preservative free on 1997-12-18. It is used to treat bacterial pneumonia, bacteroides infections, bronchitis, chlamydia infections, and escherichia coli infections amongst others in the USA.
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Therapeutic Areas
Therapeutic Area | MeSH |
|---|---|
| infections | D007239 |
| respiratory tract diseases | D012140 |
| otorhinolaryngologic diseases | D010038 |
| urogenital diseases | D000091642 |
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Alatrofloxacin mesylate
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| TROVAN PRESERVATIVE FREE | Mylan | N-020760 DISCN | 1997-12-18 | 2 products |
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Labels
FDA
EMA
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Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| bacterial pneumonia | EFO_1001272 | D018410 | J15.9 |
| bacteroides infections | EFO_1000832 | D001442 | — |
| bronchitis | — | D001991 | J40 |
| chlamydia infections | EFO_0007205 | D002690 | A74.9 |
| escherichia coli infections | EFO_1001318 | D004927 | B96.20 |
| gonorrhea | DOID_7551 | D006069 | A54 |
| haemophilus infections | EFO_1001127 | D006192 | — |
| klebsiella infections | EFO_1001353 | D007710 | — |
| pseudomonas infections | EFO_0001076 | D011552 | — |
| sinusitis | EFO_0007486 | D012852 | J32 |
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Agency Specific
FDA
EMA
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Patent Expiration
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ATC Codes
No data
HCPCS
Code | Description |
|---|---|
| J0200 | Injection, alatrofloxacin mesylate, 100 mg |
Clinical
Clinical Trials
49 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | 1 | 1 | 3 |
| Prehypertension | D058246 | — | — | — | 1 | — | 1 | ||
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | — | — | — | 1 | — | 1 |
| Myocardial infarction | D009203 | EFO_0000612 | I21 | — | — | — | 1 | — | 1 |
Indications Phases 3
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Sickle cell anemia | D000755 | EFO_0000697 | D57 | 1 | 2 | — | — | — | 3 |
| Anemia | D000740 | EFO_0004272 | D64.9 | — | 1 | — | — | — | 1 |
| Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | — | 1 | — | — | — | 1 |
| Hyperlipidemias | D006949 | EFO_0003774 | E78.5 | — | 1 | — | — | — | 1 |
| Leukemia | D007938 | C95 | 1 | 1 | — | — | — | 1 | |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 1 | 1 | — | — | — | 1 |
| Lymphoma | D008223 | C85.9 | 1 | 1 | — | — | — | 1 | |
| Memory disorders | D008569 | — | 1 | — | — | — | 1 | ||
| Schizophrenia | D012559 | EFO_0000692 | F20 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Vasodilation | D014664 | 2 | — | — | — | 2 | 4 | ||
| Healthy volunteers/patients | — | 3 | — | — | — | 1 | 4 | ||
| Pre-eclampsia | D011225 | EFO_0000668 | O14 | 1 | — | — | — | 1 | 2 |
| Heart failure | D006333 | EFO_0003144 | I50 | 1 | — | — | — | 1 | 2 |
| Inflammation | D007249 | 1 | — | — | — | 1 | 2 | ||
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | 1 | — | — | — | — | 1 |
| Pulmonary arterial hypertension | D000081029 | 1 | — | — | — | — | 1 | ||
| Vascular stiffness | D059289 | 1 | — | — | — | — | 1 | ||
| Vasoconstriction | D014661 | 1 | — | — | — | — | 1 | ||
| Hiv | D006678 | O98.7 | 1 | — | — | — | — | 1 |
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Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Cardiovascular diseases | D002318 | EFO_0000319 | I98 | — | — | — | — | 2 | 2 |
| Reperfusion injury | D015427 | — | — | — | — | 2 | 2 | ||
| Microvascular angina | D017566 | — | — | — | — | 2 | 2 | ||
| Pregnancy-induced hypertension | D046110 | O13 | — | — | — | — | 1 | 1 | |
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | — | — | — | 1 | 1 |
| Neoplasms | D009369 | C80 | — | — | — | — | 1 | 1 | |
| Chronic renal insufficiency | D051436 | N18 | — | — | — | — | 1 | 1 | |
| Myocardial ischemia | D017202 | EFO_1001375 | I20-I25 | — | — | — | — | 1 | 1 |
| Atherosclerosis | D050197 | EFO_0003914 | I25.1 | — | — | — | — | 1 | 1 |
| Insulin resistance | D007333 | EFO_0002614 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ALATROFLOXACIN MESYLATE |
| INN | alatrofloxacin |
| Description | Alatrofloxacin (Trovan IV) is a fluoroquinolone antibiotic developed by Pfizer, delivered as a mesylate salt.
|
| Classification | Small molecule |
| Drug class | antibacterials (quinolone derivatives) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | CS(=O)(=O)O.C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H]1[C@@H]2CN(c3nc4c(cc3F)c(=O)c(C(=O)O)cn4-c3ccc(F)cc3F)C[C@@H]21 |
Identifiers
| PDB | — |
| CAS-ID | 157182-32-6 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200498 |
| ChEBI ID | — |
| PubChem CID | 5489474 |
| DrugBank | — |
| UNII ID | 7QVV6I50DT (ChemIDplus, GSRS) |
Target
Agency Approved
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Alternate
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Variants
Clinical Variant
No data
Financial
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Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 433 documents
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Safety
Black-box Warning
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Adverse Events
Top Adverse Reactions
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124 adverse events reported
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