Afoxolaner
Afoxolaner is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Indications
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Agency Specific
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Clinical
Clinical Trials
25 clinical trials
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Indications Phases 4
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Paroxysmal hemoglobinuria | D006457 | Orphanet_447 | D59.12 | 2 | 1 | 2 | — | 1 | 6 |
| Geographic atrophy | D057092 | 1 | 1 | 3 | — | — | 5 | ||
| Glomerulonephritis | D005921 | N05 | — | 2 | 1 | — | — | 3 | |
| Membranoproliferative glomerulonephritis | D015432 | — | 2 | 1 | — | — | 3 | ||
| Hemolytic anemia autoimmune | D000744 | EFO_1001264 | D59.10 | — | 1 | 1 | — | — | 2 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macular degeneration | D008268 | EFO_0001365 | H35.30 | 2 | 1 | — | — | — | 2 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | 1 | — | — | — | 1 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | 1 | — | — | — | 1 |
| Iga glomerulonephritis | D005922 | EFO_0004194 | — | 1 | — | — | — | 1 | |
| Membranous glomerulonephritis | D015433 | EFO_0004254 | N03.2 | — | 1 | — | — | — | 1 |
| Lupus nephritis | D008181 | EFO_0005761 | — | 1 | — | — | — | 1 | |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | — | 1 | — | — | — | 1 |
| Endometrioid carcinoma | D018269 | — | 1 | — | — | — | 1 | ||
| Fallopian tube neoplasms | D005185 | — | 1 | — | — | — | 1 | ||
| Acinar cell carcinoma | D018267 | — | 1 | — | — | — | 1 |
Indications Phases 1
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Indications Without Phase
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | AFOXOLANER |
| INN | afoxolaner |
| Description | Afoxolaner (INN) is an insecticide and acaricide that belongs to the isoxazoline chemical compound group.
|
| Classification | Small molecule |
| Drug class | antagonists of GABA (gamma-aminobutyric acid) regulated chloride channels, antiparasitic agents |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | O=C(CNC(=O)c1ccc(C2=NOC(c3cc(Cl)cc(C(F)(F)F)c3)(C(F)(F)F)C2)c2ccccc12)NCC(F)(F)F |
Identifiers
| PDB | — |
| CAS-ID | 1093861-60-9 |
| RxCUI | 1442093 |
| ChEMBL ID | CHEMBL2219412 |
| ChEBI ID | — |
| PubChem CID | 25154249 |
| DrugBank | DB11369 |
| UNII ID | 02L07H6D0U (ChemIDplus, GSRS) |
Target
Agency Approved
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Variants
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Safety
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Adverse Events
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10 adverse events reported
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