Acyclovir
Sitavig, Xerese, Zovirax (acyclovir) is a small molecule pharmaceutical. Acyclovir was first approved as Zovirax on 1982-03-29. It is used to treat aids-related opportunistic infections, chickenpox, epstein-barr virus infections, herpes genitalis, and herpes labialis amongst others in the USA.
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Commercial
Trade Name
FDA
EMA
Sitavig, Zovirax (generic drugs available since 1997-04-22, discontinued: Avaclyr, Zovirax)
CombinationsXerese
Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Indications
FDA
EMA
Indication | Ontology | MeSH | ICD-10 |
|---|---|---|---|
| aids-related opportunistic infections | — | D017088 | — |
| chickenpox | EFO_0007204 | D002644 | B01 |
| epstein-barr virus infections | EFO_0000769 | D020031 | — |
| herpes genitalis | EFO_0007282 | D006558 | A60 |
| herpes labialis | EFO_1001347 | D006560 | B00.1 |
| herpes simplex | — | D006561 | B00 |
| herpes simplex encephalitis | — | D020803 | B00.4 |
| herpes zoster | EFO_0006510 | D006562 | B02 |
| herpes zoster ophthalmicus | EFO_0007403 | D006563 | B02.3 |
Agency Specific
FDA
EMA
Expiration | Code | ||
|---|---|---|---|
ACYCLOVIR, AVACLYR, FERA PHARMS LLC | |||
| 2026-03-29 | ODE-235 | ||
ATC Codes
D: Dermatologicals
— D06: Antibiotics and chemotherapeutics for dermatological use
— D06B: Chemotherapeutics for topical use
— D06BB: Antivirals, topical
— D06BB03: Aciclovir
— D06BB53: Aciclovir, combinations
J: Antiinfectives for systemic use
— J05: Antivirals for systemic use
— J05A: Direct acting antivirals
— J05AB: Nucleosides and nucleotides excl. reverse transcriptase inhibitors
— J05AB01: Aciclovir
S: Sensory organ drugs
— S01: Ophthalmologicals
— S01A: Antiinfective ophthalmologics
— S01AD: Antivirals, ophthalmologic
— S01AD03: Aciclovir
HCPCS
Code | Description |
|---|---|
| J0133 | Injection, acyclovir, 5 mg |
Clinical
Clinical Trials
112 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hiv infections | D015658 | EFO_0000764 | B20 | 2 | 6 | 7 | 3 | 13 | 29 |
| Herpes simplex | D006561 | B00 | 1 | 4 | 10 | 1 | 4 | 17 | |
| Herpes labialis | D006560 | EFO_1001347 | B00.1 | 1 | 4 | 7 | 1 | — | 13 |
| Herpes genitalis | D006558 | EFO_0007282 | A60 | — | 2 | 3 | 5 | 2 | 12 |
| Herpetic keratitis | D016849 | EFO_0007308 | — | — | 2 | 1 | — | 3 | |
| Healthy volunteers/patients | — | 1 | — | — | 1 | — | 2 | ||
| Herpes zoster | D006562 | EFO_0006510 | B02 | — | — | 1 | 1 | — | 2 |
| Relapsing-remitting multiple sclerosis | D020529 | EFO_0003929 | — | — | — | 1 | — | 1 | |
| Viral pneumonia | D011024 | EFO_0007541 | J12.9 | — | — | — | 1 | — | 1 |
| Papillomavirus infections | D030361 | — | — | — | 1 | — | 1 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Multiple sclerosis | D009103 | EFO_0003885 | G35 | 3 | — | 1 | — | — | 4 |
| Ulcer | D014456 | MPATH_579 | — | 2 | 1 | — | 1 | 3 | |
| Infections | D007239 | EFO_0000544 | — | — | 1 | — | 1 | 2 | |
| Chickenpox | D002644 | EFO_0007204 | B01 | — | 1 | 1 | — | — | 2 |
| Respiratory tract infections | D012141 | J06.9 | — | — | 1 | — | — | 1 | |
| Covid-19 | D000086382 | U07.1 | — | — | 1 | — | — | 1 | |
| Meniere disease | D008575 | EFO_0006862 | H81.0 | — | 1 | 1 | — | — | 1 |
| Bone marrow transplantation | D016026 | — | — | 1 | — | — | 1 | ||
| Cytomegalovirus | D003587 | — | — | 1 | — | — | 1 | ||
| Coinfection | D060085 | — | 1 | 1 | — | — | 1 |
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Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Non-small-cell lung carcinoma | D002289 | — | 1 | — | — | — | 1 | ||
| Large b-cell lymphoma diffuse | D016403 | C83.3 | 1 | 1 | — | — | — | 1 | |
| Castration-resistant prostatic neoplasms | D064129 | — | 1 | — | — | — | 1 | ||
| Precursor cell lymphoblastic leukemia-lymphoma | D054198 | C91.0 | 1 | 1 | — | — | — | 1 | |
| Biphenotypic leukemia acute | D015456 | C95.0 | 1 | 1 | — | — | — | 1 | |
| Philadelphia chromosome | D010677 | 1 | 1 | — | — | — | 1 | ||
| Kidney diseases | D007674 | EFO_0003086 | N08 | 1 | 1 | — | — | — | 1 |
| Kidney transplantation | D016030 | 1 | 1 | — | — | — | 1 | ||
| Critical illness | D016638 | — | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neonatal sepsis | D000071074 | HP_0040187 | 1 | — | — | — | — | 1 | |
| Simplexvirus | D018139 | 1 | — | — | — | — | 1 | ||
| Hemorrhoids | D006484 | EFO_0009552 | K64 | 1 | — | — | — | — | 1 |
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lymphatic diseases | D008206 | HP_0100763 | — | — | — | — | 3 | 3 | |
| Aseptic meningitis | D008582 | EFO_1000823 | G03.0 | — | — | — | — | 1 | 1 |
| Cerebral hemorrhage | D002543 | — | — | — | — | 1 | 1 | ||
| Subarachnoid hemorrhage | D013345 | EFO_0000713 | I60 | — | — | — | — | 1 | 1 |
| Drug monitoring | D016903 | — | — | — | — | 1 | 1 | ||
| Facial paralysis | D005158 | G51.0 | — | — | — | — | 1 | 1 | |
| Molluscum contagiosum | D008976 | EFO_0007375 | B08.1 | — | — | — | — | 1 | 1 |
| Uveitis | D014605 | EFO_1001231 | H20.9 | — | — | — | — | 1 | 1 |
| Acute kidney injury | D058186 | HP_0001919 | N17 | — | — | — | — | 1 | 1 |
| Repeat cesarean section | D017604 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | ACYCLOVIR |
| INN | aciclovir |
| Description | Acyclovir is an oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. It has a role as an antiviral drug and an antimetabolite. It is an oxopurine and a member of 2-aminopurines. It is functionally related to a guanine. |
| Classification | Small molecule |
| Drug class | antivirals: antivirals (acyclovir type) |
| Image (chem structure or protein) | |
| Structure (InChI/SMILES or Protein Sequence) | Nc1nc2c(ncn2COCCO)c(=O)[nH]1 |
Identifiers
| PDB | — |
| CAS-ID | 59277-89-3 |
| RxCUI | 281 |
| ChEMBL ID | CHEMBL184 |
| ChEBI ID | 2453 |
| PubChem CID | 135398513 |
| DrugBank | DB00787 |
| UNII ID | X4HES1O11F (ChemIDplus, GSRS) |
Target
Agency Approved
No data
Alternate
No data
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 24,076 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2,080 adverse events reported
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