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Abexinostat
Abexinostat is a small molecule pharmaceutical. It is currently being investigated in clinical studies. The pharmaceutical is active against histone deacetylase 1. In addition, it is known to target histone deacetylase 3.
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Commercial
Therapeutic Areas
No data
Trade Name
FDA
EMA
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Drug Products
FDA
EMA
New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
No data
Labels
FDA
EMA
No data
Indications
FDA
EMA
No data
Agency Specific
FDA
EMA
No data
Patent Expiration
No data
ATC Codes
No data
HCPCS
No data
Clinical
Clinical Trials
15 clinical trials
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Indications Phases 4
No data
Indications Phases 3
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Renal cell carcinomaD002292——1——1
Indications Phases 2
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
Non-hodgkin lymphomaD008228C85.942———4
Hodgkin diseaseD006689C8131———3
Large b-cell lymphoma diffuseD016403C83.311———2
Follicular lymphomaD008224C82—2———2
LymphomaD008223C85.921———2
SarcomaD01250911———1
Indications Phases 1
Indication
MeSH
Ontology
ICD-10
Ph 1
Ph 2
Ph 3
Ph 4
Other
Total
NeoplasmsD009369C802————2
Multiple myelomaD009101C90.02————2
B-cell chronic lymphocytic leukemiaD015451C91.12————2
Breast neoplasmsD001943EFO_0003869C501————1
Ovarian neoplasmsD010051EFO_0003893C561————1
Endometrioid carcinomaD0182691————1
Fallopian tube neoplasmsD0051851————1
Urologic neoplasmsD014571C64-C681————1
Non-small-cell lung carcinomaD0022891————1
Lung neoplasmsD008175C34.901————1
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Indications Without Phase
No data
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
Drug common nameABEXINOSTAT
INNabexinostat
Description
3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)-oxomethyl]phenoxy]ethyl]-2-benzofurancarboxamide is a member of benzofurans.
Classification
Small molecule
Drug classenzyme inhibitors: histone deacetylase inhibitors
Image (chem structure or protein)
Structure (InChI/SMILES or Protein Sequence)
CN(C)Cc1c(C(=O)NCCOc2ccc(C(=O)NO)cc2)oc2ccccc12
Identifiers
PDB—
CAS-ID783355-60-2
RxCUI—
ChEMBL IDCHEMBL2103863
ChEBI ID—
PubChem CID11749858
DrugBankDB12565
UNII IDIYO470654U (ChemIDplus, GSRS)
Target
Agency Approved
HDAC1
HDAC1
Organism
Homo sapiens
Gene name
HDAC1
Gene synonyms
RPD3L1
NCBI Gene ID
3065
Protein name
histone deacetylase 1
Protein synonyms
Protein deacetylase HDAC1, Protein decrotonylase HDAC1, reduced potassium dependency, yeast homolog-like 1
Uniprot ID
Q92534
Mouse ortholog
Hdac1 (433759)
histone deacetylase 1 (P97476)
Alternate
HDAC3
HDAC3
Organism
Homo sapiens
Gene name
HDAC3
Gene synonyms
NCBI Gene ID
8841
Protein name
histone deacetylase 3
Protein synonyms
Protein deacetylase HDAC3, Protein deacylase HDAC3, RPD3-2, SMAP45
Uniprot ID
Q9UEV0
Mouse ortholog
Hdac3 (15183)
histone deacetylase 3 (Q3UM33)
Variants
Clinical Variant
No data
Financial
No data
Trends
PubMed Central
Top Terms for Disease or Syndrome:
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Additional graphs summarizing 428 documents
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Safety
Black-box Warning
No Black-box warning
Adverse Events
Top Adverse Reactions
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2 adverse events reported
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