Turoctocog alfa

Status : approved

Description

Turoctocog alfa is a recombinant factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the N-terminus and 11 amino acids from the C-terminus of the naturally occurring B-domain. Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human- or animal-derived materials. During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification process allowing isolation of the intact rFVIII. It was first launched in Germany in January 2014 and has been approved in the US, EU and Japan.

Dosage

Form Route Strength
Kit; powder for solution intravenous 1000 unit
Kit; powder for solution intravenous 1500 unit
Kit; powder for solution intravenous 2000 unit
Kit; powder for solution intravenous 250 unit
Kit; powder for solution intravenous 3000 unit
Kit; powder for solution intravenous 500 unit

Chemical Classification

Peptides

Organic Compounds

Organic Acids

Carboxylic Acids and Derivatives

Amino Acids, Peptides, and Analogues

Brands

name Dosage form Country
Zonovate kit; powder for solution Canada
Zonovate kit; powder for solution Canada
Zonovate kit; powder for solution Canada
Zonovate kit; powder for solution Canada
Zonovate kit; powder for solution Canada
Zonovate kit; powder for solution Canada

Calculated Property

kind Value Source