Tixocortol

Status : approved

Therapeutic Classification

INTESTINAL ANTIINFLAMMATORY AGENTS

ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS

Description

Tixocortol is a corticosteroid used as an intestinal anti-inflammatory and decongestant.

Dosage

Form Route Strength
Suspension rectal 250 mg

Chemical Classification

Salt : Tixocortol pivalate

Brands

name Dosage form Country
Rectovalone 250mg/100ml suspension Canada

Calculated Property

kind Value Source
logP 2.42 ALOGPS
logS -4 ALOGPS
Water Solubility 4.28e-02 g/l ALOGPS
logP 2.32 ChemAxon
IUPAC Name (1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-14-(2-sulfanylacetyl)tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one ChemAxon
Traditional IUPAC Name tixocortol ChemAxon
Molecular Weight 378.53 ChemAxon
Monoisotopic Weight 378.18648062 ChemAxon
SMILES [H][C@@]12CC[C@](O)(C(=O)CS)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C ChemAxon
Molecular Formula C21H30O4S ChemAxon
InChI InChI=1S/C21H30O4S/c1-19-7-5-13(22)9-12(19)3-4-14-15-6-8-21(25,17(24)11-26)20(15,2)10-16(23)18(14)19/h9,14-16,18,23,25-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1 ChemAxon
InChIKey YWDBSCORAARPPF-VWUMJDOOSA-N ChemAxon
Polar Surface Area (PSA) 74.6 ChemAxon
Refractivity 103.53 ChemAxon
Polarizability 41.96 ChemAxon
Rotatable Bond Count 2 ChemAxon
H Bond Acceptor Count 4 ChemAxon
H Bond Donor Count 3 ChemAxon
pKa (strongest acidic) 9.57 ChemAxon
pKa (strongest basic) -2.8 ChemAxon
Physiological Charge 0 ChemAxon
Number of Rings 4 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 1 ChemAxon
MDDR-Like Rule 0 ChemAxon