2',5'-Oligoadenylate Synthetase

An enzyme that catalyzes the conversion of ATP into a series of (2′-5′) linked oligoadenylates and pyrophosphate in the presence of double-stranded RNA. These oligonucleotides activate an endoribonuclease (RNase L) which cleaves single-stranded RNA. Interferons can act as inducers of these reactions.

2′,5′-Oligoadenylate Synthetase