TASQ

Synonyms :
tasquinimod

Status : investigational

Description

The quinoline-3-carboxamide anti-angiogenic agent, tasquinimod, enhances the anti-prostate cancer efficacy of androgen ablation and taxotere without effecting serum PSA directly in human xenografts

Used

Investigated for use/treatment in prostate cancer.

Chemical Classification

This compound belongs to the class of organic compounds known as quinoline-3-carboxamides. These are quinolines in which the quinoline ring system is substituted by one carboxamide group at the 3-position.

Quinoline-3-carboxamides

Organic compounds

Organoheterocyclic compounds

Quinolines and derivatives

Quinoline carboxamides

Chemical Name

tasquinimod

Calculated Property

kind Value Source
logP 1.25 ALOGPS
logS -2 ALOGPS
Water Solubility 1.78e+00 g/l ALOGPS
logP 0.98 ChemAxon
IUPAC Name quinoline-3-carboxamide ChemAxon
Traditional IUPAC Name 3-quinolinecarboxamide ChemAxon
Molecular Weight 172.1833 ChemAxon
Monoisotopic Weight 172.063662888 ChemAxon
SMILES NC(=O)C1=CC2=CC=CC=C2N=C1 ChemAxon
Molecular Formula C10H8N2O ChemAxon
InChI InChI=1S/C10H8N2O/c11-10(13)8-5-7-3-1-2-4-9(7)12-6-8/h1-6H,(H2,11,13) ChemAxon
InChIKey InChIKey=BLTDCIWCFCUQCB-UHFFFAOYSA-N ChemAxon
Polar Surface Area (PSA) 55.98 ChemAxon
Refractivity 49.06 ChemAxon
Polarizability 17.64 ChemAxon
Rotatable Bond Count 1 ChemAxon
H Bond Acceptor Count 2 ChemAxon
H Bond Donor Count 1 ChemAxon
pKa (strongest acidic) 13.81 ChemAxon
pKa (strongest basic) 3.04 ChemAxon
Physiological Charge 0 ChemAxon
Number of Rings 2 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 1 ChemAxon
MDDR-Like Rule 0 ChemAxon