Protamine sulfate

Status : approved

Description

Protamine sulfate is a drug that reverses the anticoagulant effects of heparin by binding to it. It was originally isolated from the sperm of salmon and other species of fish but is now produced primarily through recombinant biotechnology. It is a highly cationic peptide that binds to either heparin or low molecular weight heparin (LMWH) to form a stable ion pair, which does not have anticoagulant activity. The ionic complex is then removed and broken down by the reticuloendothelial system. In large doses, protamine sulfate may also have an independent—however weak—anticoagulant effect.

Dosage

Form Route Strength
Injection, solution intravenous 10 mg/mL
Liquid intravenous 10 mg
Solution intravenous 10 mg

Chemical Classification

Peptides

Organic Compounds

Organic Acids

Carboxylic Acids and Derivatives

Amino Acids, Peptides, and Analogues

Brands

name Dosage form Country
Protamine Sulfate injection, solution US
Protamine Sulfate injection, solution US
Protamine Sulfate injection, solution US
Protamine Sulfate injection, solution US
Protamine Sulfate Inj 10mg/ml USP liquid Canada
Protamine Sulfate Injection USP solution Canada
Protamine Sulfate Injection USP liquid Canada
Protamine Sulfate Injection, USP solution Canada

Calculated Property

kind Value Source