Potassium Iodide

Synonyms :
Kaliumiodid, KI, Potassium iodide

Status : approved

Therapeutic Classification

EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS

RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
EXPECTORANTS, EXCL. COMBINATIONS WITH COUGH SUPPRESSANTS

Description

Saturated solution of Potassium Iodide (SSKI) is used pharmaceutically for emergency use in patients experiencing acute symptoms of severe hyperglycemia (also known as thyroid storm or thyrotoxic crisis). SSKI can also be used for radioiodine-contamination emergencies or in preparation of thyrotoxic patients for thyroidectomy.

Used

Potassium Iodide is oral antithyroid agent. Potassium Iodide is used as an adjunct to other antithyroid agents in the treatment of hyperthyroidism and thyrotoxicosis and preoperatively to induce thyroid involution.

Dosage

Form Route Strength
Liquid topical 750 mg
Liquid topical 70; 50; 850 mg/mL; mg/mL; mg/mL
Tincture topical 25 mg
Tincture topical 50 mg
Tincture topical 2.5 %
Tablet oral 130 mg
Tablet oral 65 mg
Syrup oral 4.2 mg
Syrup oral 5 mg
Solution oral 65 mg/mL
Liquid topical 2.5 %
Liquid topical 5 %

Pharmacodynamics

It works in the thyroid gland. By inhibiting thyroid hormone synthesis and release, thyroid gland vascularity is reduced, thyroid gland tissue becomes firmer, thyroid cell size is reduced, follicular colloid reaccumulates, and bound iodine levels increase. As a protectant following radiation exposure, KI blocks the uptake of radioactive iodine isotopes by the thyroid gland thereby minimizing the risk of radiation-induced thyroid neoplasms.

Chemical Classification

This compound belongs to the class of inorganic compounds known as alkali metal iodides. These are inorganic compounds in which the largest halogen atom is Iodine, and the heaviest metal atom is an alkali metal.

Alkali metal iodides

Inorganic compounds

Mixed metal/non-metal compounds

Alkali metal salts

Alkali metal iodides

Chemical Name

Kaliumiodid

Brands

name Dosage form Country
Diodine liquid Canada
Humco Strong Iodine Tincture liquid US
Iodine Tct 2.5% BP tincture Canada
Iodine Tct 5% Cf tincture Canada
Iodine Tincture 21/2% tincture Canada
Iosat tablet US
Iosat tablet US
Mathieu Cough Syrup syrup Canada
Metrate syrup Canada
Thyroblock Tab 130mg tablet Canada
Thyrosafe tablet Canada
Thyroshield solution US
Thyroshield solution US
Tincture Of Iodine liquid Canada
Tincture Of Iodine 2.5% tincture Canada
Tincture Of Iodine 5% liquid Canada
Vito Bronches Sirop syrup Canada

Drug Drug Interactions

  •  Aliskiren  : Potassium Salts may enhance the hyperkalemic effect of Aliskiren.
  •  Eplerenone  : May enhance the hyperkalemic effect of Potassium Salts.
  •  Heparin  : May enhance the hyperkalemic effect of Potassium Salts.
  •  Lithium  : Potassium Iodide may enhance the hypothyroid effect of Lithium.

Calculated Property

kind Value Source
logP 0.2 ChemAxon
IUPAC Name potassium iodide ChemAxon
Traditional IUPAC Name potassium iodide ChemAxon
Molecular Weight 166.0028 ChemAxon
Monoisotopic Weight 165.868175281 ChemAxon
SMILES [K+].[I-] ChemAxon
Molecular Formula IK ChemAxon
InChI InChI=1S/HI.K/h1H;/q;+1/p-1 ChemAxon
InChIKey InChIKey=NLKNQRATVPKPDG-UHFFFAOYSA-M ChemAxon
Polar Surface Area (PSA) 0 ChemAxon
Refractivity 0 ChemAxon
Polarizability 1.78 ChemAxon
Rotatable Bond Count 0 ChemAxon
H Bond Acceptor Count 0 ChemAxon
H Bond Donor Count 0 ChemAxon
Physiological Charge 1 ChemAxon
Number of Rings 0 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 0 ChemAxon
MDDR-Like Rule 0 ChemAxon

Target within organism

  • Tyrosine : in Human