Paraldehyde

Status : approved

Therapeutic Classification

HYPNOTICS AND SEDATIVES

NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES

Description

Paraldehyde is the cyclic trimer of acetaldehyde molecules. It was introduced into clinical practice in the UK by the Italian physician Vincenzo Cervello in 1882. It is a central nervous system depressant and was soon found to be an effective anticonvulsant, hypnotic and sedative. It was included in some cough medicines as an expectorant (though there is no known mechanism for this function beyond the placebo effect).

Dosage

Form Route Strength
Liquid intramuscular; intravenous 100 %

Chemical Classification

This compound belongs to the class of organic compounds known as trioxanes. These are compounds containing a six-member aliphatic saturated heterocycle made up of three oxygen atoms and three carbon atoms.

Trioxanes

Organic compounds

Organoheterocyclic compounds

Trioxanes

Brands

name Dosage form Country
Paraldehyde Inj Bp 100% liquid Canada
Paraldehyde Injection BP liquid Canada
Paraldehyde Injection BP liquid Canada

Drug Drug Interactions

  •  Alfentanil  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Alprazolam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Amitriptyline  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Amobarbital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Amoxapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Aripiprazole  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Asenapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Azelastine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Baclofen  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Brexpiprazole  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Brimonidine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Bromazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Brompheniramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Buprenorphine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Buspirone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Butabarbital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Butalbital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Butorphanol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Carbamazepine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Carbinoxamine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Carisoprodol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Cetirizine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Chlordiazepoxide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Chlorphenamine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Chlorpromazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Chlorzoxazone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clemastine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clidinium  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clobazam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clomipramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clonazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clonidine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clorazepate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Clozapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Codeine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Cyclizine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Cyclobenzaprine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Cyproheptadine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Dantrolene  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Desflurane  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Desipramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Desloratadine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Dexbrompheniramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Diazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Difenoxin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Dihydrocodeine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Dimenhydrinate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Diphenhydramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Diphenoxylate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Disulfiram  : May increase the serum concentration of Paraldehyde.
  •  Doxepin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Doxylamine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Dronabinol  : May enhance the CNS depressant effect of CNS Depressants.
  •  Dronabinol  : May enhance the CNS depressant effect of CNS Depressants.
  •  Droperidol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Efavirenz  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Entacapone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Estazolam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Eszopiclone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ethosuximide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ethotoin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ezogabine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Felbamate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Fentanyl  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Fexofenadine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Flibanserin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Flunarizine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Flupentixol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Fluphenazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Flurazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Fluticasone Propionate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Fosphenytoin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Gabapentin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  gabapentin enacarbil  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Gamma Hydroxybutyric Acid  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Guanfacine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Haloperidol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Hydrocodone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Hydromorphone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Hydroxyzine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Iloperidone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Imipramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Isoflurane  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ketamine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Lamotrigine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Levetiracetam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Levocabastine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Levocetirizine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Levodopa  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Levorphanol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Loratadine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Lorazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Loxapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Lurasidone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Magnesium Sulfate  : May enhance the CNS depressant effect of CNS Depressants.
  •  Maprotiline  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Meclizine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Meprobamate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Metaxalone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Methadone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Methocarbamol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Methohexital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Methotrimeprazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Methsuximide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Metyrosine  : CNS Depressants may enhance the sedative effect of Metyrosine.
  •  Midazolam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Minocycline  : May enhance the CNS depressant effect of CNS Depressants.
  •  Mirtazapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Morphine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Nabilone  : May enhance the CNS depressant effect of CNS Depressants.
  •  Nalbuphine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Nitrazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Nitrous oxide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Nortriptyline  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Olanzapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Olopatadine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Orphenadrine  : CNS Depressants may enhance the CNS depressant effect of Orphenadrine.
  •  Oxazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Oxycodone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Oxymorphone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Paliperidone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pentazocine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pentobarbital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Perampanel  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Perphenazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pethidine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Phenobarbital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Phenytoin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pimozide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pipotiazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pizotifen  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pomalidomide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Pramipexole  : CNS Depressants may enhance the sedative effect of Pramipexole.
  •  Pregabalin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Primidone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Prochlorperazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Promazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Promethazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Propofol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Protriptyline  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Quazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Quetiapine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ramelteon  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Remifentanil  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Reserpine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Risperidone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ropinirole  : CNS Depressants may enhance the sedative effect of Ropinirole.
  •  Rotigotine  : CNS Depressants may enhance the sedative effect of Rotigotine.
  •  Rufinamide  : May enhance the adverse/toxic effect of CNS Depressants. Specifically, sleepiness and dizziness may be enhanced.
  •  Scopolamine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Secobarbital  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Sevoflurane  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Sodium oxybate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Stiripentol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Sufentanil  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Suvorexant  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tapentadol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tasimelteon  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Temazepam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tetrabenazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Thalidomide  : CNS Depressants may enhance the CNS depressant effect of Thalidomide.
  •  Thioridazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Thiothixene  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tiagabine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tizanidine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tolcapone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Topiramate  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Tramadol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Triazolam  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Trifluoperazine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Trimipramine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Triprolidine  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Vigabatrin  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Zaleplon  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ziconotide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Ziprasidone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Zolpidem  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Zonisamide  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Zopiclone  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.
  •  Zuclopenthixol  : CNS Depressants may enhance the CNS depressant effect of Paraldehyde.

Calculated Property

kind Value Source
logP 0.33 ALOGPS
logS 0.13 ALOGPS
Water Solubility 1.77e+02 g/l ALOGPS
logP 0.88 ChemAxon
IUPAC Name 2,4,6-trimethyl-1,3,5-trioxane ChemAxon
Traditional IUPAC Name paral ChemAxon
Molecular Weight 132.1577 ChemAxon
Monoisotopic Weight 132.07864425 ChemAxon
SMILES CC1OC(C)OC(C)O1 ChemAxon
Molecular Formula C6H12O3 ChemAxon
InChI InChI=1S/C6H12O3/c1-4-7-5(2)9-6(3)8-4/h4-6H,1-3H3 ChemAxon
InChIKey SQYNKIJPMDEDEG-UHFFFAOYSA-N ChemAxon
Polar Surface Area (PSA) 27.69 ChemAxon
Refractivity 32.09 ChemAxon
Polarizability 14.15 ChemAxon
Rotatable Bond Count 0 ChemAxon
H Bond Acceptor Count 3 ChemAxon
H Bond Donor Count 0 ChemAxon
pKa (strongest basic) -4 ChemAxon
Physiological Charge 0 ChemAxon
Number of Rings 1 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 0 ChemAxon
MDDR-Like Rule 0 ChemAxon