Status : investigational


K101 is developed by Moberg Derma for the treatment of onychomycosis (nail fungus) as the primary indication.


Investigated for use/treatment in fungal infections.

Mechanism Of Action

K101 is a topical solution applied once-daily on affected nails during treatment periods of 3-6 months. In pilot studies, K101 has shown promising results and provides important benefits compared to existing treatment alternatives. There is a significant need for more efficacious topical treatments. For more severe cases of the disease where more than 50% of the nail is affected, the only available options are oral anti-fungals which are associated with a certain risk for severe side effects.

Chemical Classification

This compound belongs to the class of organic compounds known as benzenesulfonic acids and derivatives. These are organic compounds containing a sulfonic acid or a derivative thereof that is linked to a benzene ring.

Benzenesulfonic acids and derivatives

Organic compounds


Benzene and substituted derivatives

Benzenesulfonic acids and derivatives

Calculated Property

kind Value Source
logP 3.5 ALOGPS
logS -4.6 ALOGPS
Water Solubility 7.90e-03 g/l ALOGPS
logP 4.4 ChemAxon
IUPAC Name 4-chlorophenyl 4-chlorobenzene-1-sulfonate ChemAxon
Traditional IUPAC Name mitran ChemAxon
Molecular Weight 303.161 ChemAxon
Monoisotopic Weight 301.957120226 ChemAxon
SMILES ClC1=CC=C(OS(=O)(=O)C2=CC=C(Cl)C=C2)C=C1 ChemAxon
Molecular Formula C12H8Cl2O3S ChemAxon
InChI InChI=1S/C12H8Cl2O3S/c13-9-1-5-11(6-2-9)17-18(15,16)12-7-3-10(14)4-8-12/h1-8H ChemAxon
Polar Surface Area (PSA) 43.37 ChemAxon
Refractivity 70.55 ChemAxon
Polarizability 28.27 ChemAxon
Rotatable Bond Count 3 ChemAxon
H Bond Acceptor Count 2 ChemAxon
H Bond Donor Count 0 ChemAxon
Physiological Charge 0 ChemAxon
Number of Rings 2 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 1 ChemAxon
MDDR-Like Rule 0 ChemAxon