Status : investigational


Highly potent and selective non-competitive antagonist acting at the strychnine-insensitive glycine binding site of the NMDA receptor-channel complex (Kd = 0.8 nM). Gavestinel displays > 1000-fold selectivity over NMDA, AMPA and kainate binding sites and is orally bioavailable and active in vivo.

Chemical Classification

Calculated Property

kind Value Source

Affected organism

Humans and other mammals

Target within organism

  • Glutamate (NMDA) receptor : in Human