Formic Acid

Synonyms :
Aminic acid, Formate, Formylic acid, Hydrogen carboxylic acid, Methanoic acid

Status : experimental

Category

Anti-Bacterial Agents

Description

Formic acid (systematically called methanoic acid) is the simplest carboxylic acid. It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. The principal use of formic acid is as a preservative and antibacterial agent in livestock feed. [Wikipedia]

Toxic Effect

ORAL (LD50): Acute: 700 mg/kg [Mouse]. 1100 mg/kg [Rat]. 4000 mg/kg [Dog].

Absorption

Formic acid is readily metabolized and eliminated by the body.

Chemical Classification

This compound belongs to the class of organic compounds known as carboxylic acids. These are compounds containing a carboxylic acid group with the formula -C(=O)OH.

Carboxylic acids

Organic compounds

Organic acids and derivatives

Carboxylic acids and derivatives

Carboxylic acids

Chemical Name

Aminic acid

Calculated Property

kind Value Source
logP -0.47 ALOGPS
logS 1.02 ALOGPS
Water Solubility 4.77e+02 g/l ALOGPS
logP -0.27 ChemAxon
IUPAC Name formic acid ChemAxon
Traditional IUPAC Name formic acid ChemAxon
Molecular Weight 46.0254 ChemAxon
Monoisotopic Weight 46.005479308 ChemAxon
SMILES OC=O ChemAxon
Molecular Formula CH2O2 ChemAxon
InChI InChI=1S/CH2O2/c2-1-3/h1H,(H,2,3) ChemAxon
InChIKey InChIKey=BDAGIHXWWSANSR-UHFFFAOYSA-N ChemAxon
Polar Surface Area (PSA) 37.3 ChemAxon
Refractivity 8.15 ChemAxon
Polarizability 3.37 ChemAxon
Rotatable Bond Count 0 ChemAxon
H Bond Acceptor Count 2 ChemAxon
H Bond Donor Count 1 ChemAxon
pKa (strongest acidic) 4.27 ChemAxon
Physiological Charge -1 ChemAxon
Number of Rings 0 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 0 ChemAxon
MDDR-Like Rule 0 ChemAxon

Target within organism

  • Heme oxygenase 1 : in Human
  • Ribonuclease pancreatic : in Human
  • Dihydroorotate dehydrogenase (quinone) : in Escherichia coli (strain K12)
  • (S)-2-haloacid dehalogenase : in Xanthobacter autotrophicus
  • Beta-lactamase OXA-2 : in Salmonella typhimurium
  • Catalase : in Proteus mirabilis
  • Signal recognition particle protein : in Thermus aquaticus
  • Streptavidin : in Streptomyces avidinii
  • Methylglyoxal synthase : in Shigella flexneri
  • C-terminal-binding protein 1 : in Human
  • 6-phosphogluconolactonase : in Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
  • Citrate lyase subunit beta-like protein : in Mycobacterium tuberculosis
  • Peripheral plasma membrane protein CASK : in Human
  • Guanylate kinase : in Mycobacterium tuberculosis
  • Probable butyrate kinase 2 : in Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
  • Gamma-glutamylaminecyclotransferase : in Human
  • Parvalbumin alpha : in Human
  • Acylphosphatase-2 : in Human
  • Uncharacterized protein : in Bacillus cereus (strain ATCC 14579 / DSM 31)
  • Arginine N-succinyltransferase subunit alpha : in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Putative mannose-6-phosphate isomerase YvyI : in Bacillus subtilis (strain 168)
  • Nitric oxide synthase, brain : in Human
  • ABC-type transporter, periplasmic subunit : in Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
  • Probable phosphatase YcdX : in Escherichia coli (strain K12)
  • Phenazine biosynthesis protein PhzD : in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • Oxalate decarboxylase OxdC : in Bacillus subtilis (strain 168)
  • Putative ketoacyl reductase : in Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
  • Gephyrin : in Human
  • Glyoxalase family protein : in Bacillus cereus (strain ATCC 14579 / DSM 31)
  • Cytohesin-2 : in Human
  • Glutaconyl-CoA decarboxylase subunit alpha : in Acidaminococcus fermentans (strain ATCC 25085 / DSM 20731 / VR4)
  • Transcriptional regulator, IclR family : in Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
  • Catalase : in Helicobacter pylori (strain ATCC 700392 / 26695)
  • Putative L-rhamnose mutarotase : in Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
  • Glutathione S-transferase : in Plasmodium falciparum
  • Hypoxanthine-guanine phosphoribosyltransferase : in Trypanosoma cruzi
  • Glutaminase 1 : in Bacillus subtilis (strain 168)
  • Glutaminase 1 : in Escherichia coli (strain K12)
  • Molybdopterin synthase catalytic subunit : in Escherichia coli (strain K12)
  • Aminotransferase, putative : in Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
  • Iron binding protein FbpA : in Pasteurella haemolytica
  • DNA gyrase subunit B : in Thermus thermophilus
  • Putative hydroxypyruvate isomerase YgbM : in Escherichia coli (strain K12)
  • Delta-aminolevulinic acid dehydratase : in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
  • 3-phosphoshikimate 1-carboxyvinyltransferase : in Escherichia coli (strain K12)
  • Subtilisin Carlsberg : in Bacillus licheniformis
  • Fibroblast growth factor 1 : in Human
  • Peptide deformylase : in Escherichia coli (strain K12)
  • Para-aminobenzoate synthase component 1 : in Escherichia coli (strain K12)
  • Carbonic anhydrase 2 : in Human