Eperisone

Synonyms :
(2RS)-1-(4-ethylphenyl)-2-methyl-3-(1-piperidyl)propan-1-one, Eperison, Eperisona, Epérisone, Eperisonum

Status : approved

Therapeutic Classification

MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS

MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANTS
MUSCLE RELAXANTS, CENTRALLY ACTING AGENTS

Description

Eperisone is an antispasmodic drug which relaxes both skeletal muscles and vascular smooth muscles, and demonstrates a variety of effects such as reduction of myotonia, improvement of circulation, and suppression of the pain reflex. It is not approved for use in the United States, but is available in other countries like India, South Korea, and Bangladesh.

Chemical Classification

Salt : Eperisone Hydrochloride

Chemical Name

(2RS)-1-(4-ethylphenyl)-2-methyl-3-(1-piperidyl)propan-1-one

Drug Drug Interactions

  •  Methocarbamol  : May enhance the adverse/toxic effect of Methocarbamol.

Calculated Property

kind Value Source
logP 4.27 ALOGPS
logS -3.6 ALOGPS
Water Solubility 6.17e-02 g/l ALOGPS
logP 4.01 ChemAxon
IUPAC Name 1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one ChemAxon
Traditional IUPAC Name (+-)-eperisone ChemAxon
Molecular Weight 259.3865 ChemAxon
Monoisotopic Weight 259.193614427 ChemAxon
SMILES CCC1=CC=C(C=C1)C(=O)C(C)CN1CCCCC1 ChemAxon
Molecular Formula C17H25NO ChemAxon
InChI InChI=1/C17H25NO/c1-3-15-7-9-16(10-8-15)17(19)14(2)13-18-11-5-4-6-12-18/h7-10,14H,3-6,11-13H2,1-2H3 ChemAxon
InChIKey InChIKey=SQUNAWUMZGQQJD-UHFFFAOYNA-N ChemAxon
Polar Surface Area (PSA) 20.31 ChemAxon
Refractivity 80.95 ChemAxon
Polarizability 31.74 ChemAxon
Rotatable Bond Count 5 ChemAxon
H Bond Acceptor Count 2 ChemAxon
H Bond Donor Count 0 ChemAxon
pKa (strongest acidic) 16.34 ChemAxon
pKa (strongest basic) 8.77 ChemAxon
Physiological Charge 1 ChemAxon
Number of Rings 2 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 1 ChemAxon
MDDR-Like Rule 0 ChemAxon