Capromab

Synonyms :
Capromab pendetide, In 111 Capromab pendetide, Indium (111In) capromab pendetide, Indium 111 Capromab Pendetide

Status : approved

Category

Indicators and Reagents

Description

Capromab is a Murine IgG1 monoclonal 7E11-C5.3 antibody that recognizes prostate specific membrane antigen (PSMA – also known as glutamate carboxypeptidase 2) from prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA. Pendetide acts as a chelating agent for the radionuclide indium-111. Capromab is used to image the extent of prostate cancer.

Used

For diagnosis of prostate cancer and detection of intra-pelvic metastases.

Mechanism Of Action

Binds selectively to cell-surface prostate-specific membrane antigen (PSMA) expressed on prostate tissues and tumors.

Pharmacodynamics

Binds to the prostate-specific membrane antigen, which is a cell surface protein generally overexpressed in prostate tissues and prostate cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of PSMA expressing cells and tumors.

Metabolism

Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production

Elimination Route

Approximately 10% of the administered radioisotope dose is excreted in the urine during the 72 hours following intravenous infusion.

Clearance

* 42 +/- 22 mL/hr

Volume of Distribution

* 4 ± 2.1 L

Chemical Classification

Peptides

Organic Compounds

Organic Acids

Carboxylic Acids and Derivatives

Amino Acids, Peptides, and Analogues

Chemical Name

Capromab pendetide

Calculated Property

kind Value Source

Affected organism

Humans and other mammals

Target within organism

  • Glutamate carboxypeptidase 2 : in Human