Benzydamine

Status : approved

Therapeutic Classification

STOMATOLOGICAL PREPARATIONS

ALIMENTARY TRACT AND METABOLISM
STOMATOLOGICAL PREPARATIONS
STOMATOLOGICAL PREPARATIONS

Description

Benzydamine (also known as Tantum Verde and branded in some countries as Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties for pain relief and anti-inflammatory treatment of inflammatory conditions of the mouth and throat.

Dosage

Form Route Strength
Liquid buccal 0.15 %
Liquid buccal 1.5 mg
Liquid; mouthwash/gargle buccal; oral 1.5 mg
Solution; mouthwash/gargle buccal; oral 1.5 mg
Solution oral 0.15 %
Liquid dental; oral .15 %
Solution buccal 15 mg

Chemical Classification

This compound belongs to the class of organic compounds known as indazoles. These are compounds containing an indazole, which is structurally characterized by a pyrazole fused to a benzene.

Indazoles

Organic compounds

Organoheterocyclic compounds

Benzopyrazoles

Indazoles

Salt : Benzydamine hydrochloride

Brands

name Dosage form Country
Apo-benzydamine Oral Rinse liquid Canada
Dom-benzydamine liquid Canada
Novo-benzydamine solution; mouthwash/gargle Canada
Novo-benzydamine – Oral Rinse liquid; mouthwash/gargle Canada
Nu-benzydamine Oral Rinse liquid Canada
Pharixia solution; mouthwash/gargle Canada
Ratio-benzydamine solution Canada
Sun-benz – Liq 0.15% liquid Canada
Tantum solution Canada

Calculated Property

kind Value Source
logP 3.78 ALOGPS
logS -3.8 ALOGPS
Water Solubility 4.91e-02 g/l ALOGPS
logP 3.66 ChemAxon
IUPAC Name {3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine ChemAxon
Traditional IUPAC Name tantum ChemAxon
Molecular Weight 309.413 ChemAxon
Monoisotopic Weight 309.184112373 ChemAxon
SMILES CN(C)CCCOC1=NN(CC2=CC=CC=C2)C2=CC=CC=C12 ChemAxon
Molecular Formula C19H23N3O ChemAxon
InChI InChI=1S/C19H23N3O/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16/h3-7,9-12H,8,13-15H2,1-2H3 ChemAxon
InChIKey CNBGNNVCVSKAQZ-UHFFFAOYSA-N ChemAxon
Polar Surface Area (PSA) 30.29 ChemAxon
Refractivity 105.56 ChemAxon
Polarizability 35.62 ChemAxon
Rotatable Bond Count 7 ChemAxon
H Bond Acceptor Count 3 ChemAxon
H Bond Donor Count 0 ChemAxon
pKa (strongest basic) 9.26 ChemAxon
Physiological Charge 1 ChemAxon
Number of Rings 3 ChemAxon
Bioavailability 1 ChemAxon
Rule of Five 1 ChemAxon
Ghose Filter 1 ChemAxon
MDDR-Like Rule 1 ChemAxon