Alseroxylon

Synonyms :
Alseroxylon, Egalin, Rau-Tab, Rautensin, Rauwiloid

Status : withdrawn

Description

A fat-soluble alkaloidal fraction extracted from the root of Rauwolfia serpentina, containing reserpine and other nonadrenolytic amorphous alkaloids; used as a sedative in psychoses, in mild hypertension, and as an adjunct to more potent hypotensive drugs. Alseroxylon has been discontinued in the US market.

Used

For the treatment of hypertension and as an adjunct in the management of angina pectoris.

Mechanism Of Action

The antihypertensive actions of alseroxylon are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. Alseroxylon almost irreversibly blocks the accumulation of noradrenaline and dopamine into synaptic vesicles by inhibiting the Vesicular Monoamine Transporters (VMAT). This depletion ultimately affects the carotid pressoreceptors which leads to a decrease in vascular pressure.

Pharmacodynamics

Alseroxylon is a purified extract of Rauwolfia serpentina, containing reserpine and other amorphous alkaloids. Alseroxylon is an indole alkaloid antipsychotic and antihypertensive drug known to irreversibly bind to storage vesicles of neurotransmitters such as dopamine, norepinephrine, and serotonin. This leads to depletion of the neurotransmitters and subsequent depression in humans.

Chemical Classification

Chemical Name

Alseroxylon

Calculated Property

kind Value Source

Affected organism

Humans and other mammals

Target within organism

  • Synaptic vesicular amine transporter : in Human